T-tubule function in mammalian cardiac myocytes
The transverse tubules (t-tubules) of mammalian cardiac ventricular myocytes are
invaginations of the surface membrane. Recent studies have suggested that the structure …
invaginations of the surface membrane. Recent studies have suggested that the structure …
Endoplasmic Reticulum–Plasma Membrane Junctions as Sites of Depolarization-Induced Ca2+ Signaling in Excitable Cells
RE Dixon, JS Trimmer - Annual review of physiology, 2023 - annualreviews.org
Membrane contact sites between endoplasmic reticulum (ER) and plasma membrane (PM),
or ER-PM junctions, are found in all eukaryotic cells. In excitable cells they play unique roles …
or ER-PM junctions, are found in all eukaryotic cells. In excitable cells they play unique roles …
[图书][B] Excitation-contraction coupling and cardiac contractile force
D Bers - 2001 - books.google.com
How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …
What are the links between cardiac structure and function? How does our understanding of …
Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia
Cardiomyocyte T tubules are important for regulating ion flux. Bridging integrator 1 (BIN1) is
a T-tubule protein associated with calcium channel trafficking that is downregulated in failing …
a T-tubule protein associated with calcium channel trafficking that is downregulated in failing …
Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart
AR Lyon, KT MacLeod, Y Zhang… - Proceedings of the …, 2009 - National Acad Sciences
T-tubular invaginations of the sarcolemma of ventricular cardiomyocytes contain junctional
structures functionally coupling L-type calcium channels to the sarcoplasmic reticulum …
structures functionally coupling L-type calcium channels to the sarcoplasmic reticulum …
Reduced synchrony of Ca2+ release with loss of T-tubules—a comparison to Ca2+ release in human failing cardiomyocytes
Objectives: During cardiac excitation–contraction coupling, Ca2+ release from the
sarcoplasmic reticulum (SR) occurs at the junctional complex with the T-tubules, containing …
sarcoplasmic reticulum (SR) occurs at the junctional complex with the T-tubules, containing …
BIN1 localizes the L-type calcium channel to cardiac T-tubules
The BAR domain protein superfamily is involved in membrane invagination and
endocytosis, but its role in organizing membrane proteins has not been explored. In …
endocytosis, but its role in organizing membrane proteins has not been explored. In …
Transverse tubules are a common feature in large mammalian atrial myocytes including human
MA Richards, JD Clarke, P Saravanan… - American Journal …, 2011 - journals.physiology.org
Transverse (t) tubules are surface membrane invaginations that are present in all
mammalian cardiac ventricular cells. The apposition of L-type Ca2+ channels on t tubules …
mammalian cardiac ventricular cells. The apposition of L-type Ca2+ channels on t tubules …
Cardiac transverse tubules in physiology and heart failure
KM Dibb, WE Louch, AW Trafford - Annual review of physiology, 2022 - annualreviews.org
In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma
but also a network of membrane invaginations called transverse (t-) tubules. These …
but also a network of membrane invaginations called transverse (t-) tubules. These …
Three-dimensional reconstruction of cardiac sarcoplasmic reticulum reveals a continuous network linking transverse-tubules: this organization is perturbed in heart …
C Pinali, H Bennett, JB Davenport, AW Trafford… - Circulation …, 2013 - Am Heart Assoc
Rationale: The organization of the transverse-tubular (tt) system and relationship to the
sarcoplasmic reticulum (SR) underpins cardiac excitation–contraction coupling. The …
sarcoplasmic reticulum (SR) underpins cardiac excitation–contraction coupling. The …