Adaptive deep brain stimulation: From experimental evidence toward practical implementation

WJ Neumann, R Gilron, S Little… - Movement …, 2023 - Wiley Online Library
Closed‐loop adaptive deep brain stimulation (aDBS) can deliver individualized therapy at
an unprecedented temporal precision for neurological disorders. This has the potential to …

The future of stem cell therapies for Parkinson disease

M Parmar, S Grealish, C Henchcliffe - Nature Reviews Neuroscience, 2020 - nature.com
Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …

Pathological pallidal beta activity in Parkinson's disease is sustained during sleep and associated with sleep disturbance

Z Yin, R Ma, Q An, Y Xu, Y Gan, G Zhu, Y Jiang… - Nature …, 2023 - nature.com
Parkinson's disease (PD) is associated with excessive beta activity in the basal ganglia.
Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive …

Insights and opportunities for deep brain stimulation as a brain circuit intervention

WJ Neumann, A Horn, AA Kühn - Trends in Neurosciences, 2023 - cell.com
Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into
the dynamic circuit architecture of brain disorders. This Review illustrates our current …

Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions

WJ Neumann, LA Steiner, L Milosevic - Brain, 2023 - academic.oup.com
Deep brain stimulation is a neuromodulatory treatment for managing the symptoms of
Parkinson's disease and other neurological and psychiatric disorders. Electrodes are …

Chronic embedded cortico-thalamic closed-loop deep brain stimulation for the treatment of essential tremor

E Opri, S Cernera, R Molina, RS Eisinger… - Science translational …, 2020 - science.org
Deep brain stimulation (DBS) is an approved therapy for the treatment of medically refractory
and severe movement disorders. However, most existing neurostimulators can only apply …

Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond

W Bouthour, P Mégevand, J Donoghue… - Nature Reviews …, 2019 - nature.com
Subthalamic deep brain stimulation (DBS) for Parkinson disease (PD) currently requires
laborious open-loop programming, which can mitigate the benefits of this treatment …

[HTML][HTML] Local field potentials in Parkinson's disease: a frequency-based review

Z Yin, G Zhu, B Zhao, Y Bai, Y Jiang… - Neurobiology of …, 2021 - Elsevier
Deep brain stimulation (DBS) surgery offers a unique opportunity to record local field
potentials (LFPs), the electrophysiological population activity of neurons surrounding the …

[HTML][HTML] Machine learning based brain signal decoding for intelligent adaptive deep brain stimulation

T Merk, V Peterson, R Köhler, S Haufe… - Experimental …, 2022 - Elsevier
Sensing enabled implantable devices and next-generation neurotechnology allow real-time
adjustments of invasive neuromodulation. The identification of symptom and disease …

European clinical guidelines for Tourette syndrome and other tic disorders—version 2.0. Part IV: deep brain stimulation

N Szejko, Y Worbe, A Hartmann… - European Child & …, 2022 - Springer
Abstract In 2011 the European Society for the Study of Tourette Syndrome (ESSTS)
published its first European clinical guidelines for the treatment of Tourette Syndrome (TS) …