Adaptive deep brain stimulation: From experimental evidence toward practical implementation
WJ Neumann, R Gilron, S Little… - Movement …, 2023 - Wiley Online Library
Closed‐loop adaptive deep brain stimulation (aDBS) can deliver individualized therapy at
an unprecedented temporal precision for neurological disorders. This has the potential to …
an unprecedented temporal precision for neurological disorders. This has the potential to …
The future of stem cell therapies for Parkinson disease
M Parmar, S Grealish, C Henchcliffe - Nature Reviews Neuroscience, 2020 - nature.com
Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …
Pathological pallidal beta activity in Parkinson's disease is sustained during sleep and associated with sleep disturbance
Parkinson's disease (PD) is associated with excessive beta activity in the basal ganglia.
Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive …
Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive …
Insights and opportunities for deep brain stimulation as a brain circuit intervention
Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into
the dynamic circuit architecture of brain disorders. This Review illustrates our current …
the dynamic circuit architecture of brain disorders. This Review illustrates our current …
Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions
WJ Neumann, LA Steiner, L Milosevic - Brain, 2023 - academic.oup.com
Deep brain stimulation is a neuromodulatory treatment for managing the symptoms of
Parkinson's disease and other neurological and psychiatric disorders. Electrodes are …
Parkinson's disease and other neurological and psychiatric disorders. Electrodes are …
Chronic embedded cortico-thalamic closed-loop deep brain stimulation for the treatment of essential tremor
Deep brain stimulation (DBS) is an approved therapy for the treatment of medically refractory
and severe movement disorders. However, most existing neurostimulators can only apply …
and severe movement disorders. However, most existing neurostimulators can only apply …
Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond
W Bouthour, P Mégevand, J Donoghue… - Nature Reviews …, 2019 - nature.com
Subthalamic deep brain stimulation (DBS) for Parkinson disease (PD) currently requires
laborious open-loop programming, which can mitigate the benefits of this treatment …
laborious open-loop programming, which can mitigate the benefits of this treatment …
[HTML][HTML] Local field potentials in Parkinson's disease: a frequency-based review
Deep brain stimulation (DBS) surgery offers a unique opportunity to record local field
potentials (LFPs), the electrophysiological population activity of neurons surrounding the …
potentials (LFPs), the electrophysiological population activity of neurons surrounding the …
[HTML][HTML] Machine learning based brain signal decoding for intelligent adaptive deep brain stimulation
Sensing enabled implantable devices and next-generation neurotechnology allow real-time
adjustments of invasive neuromodulation. The identification of symptom and disease …
adjustments of invasive neuromodulation. The identification of symptom and disease …
European clinical guidelines for Tourette syndrome and other tic disorders—version 2.0. Part IV: deep brain stimulation
Abstract In 2011 the European Society for the Study of Tourette Syndrome (ESSTS)
published its first European clinical guidelines for the treatment of Tourette Syndrome (TS) …
published its first European clinical guidelines for the treatment of Tourette Syndrome (TS) …