5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …

Most people who are regular consumers of psychoactive drugs are not drug addicts, nor will
they ever become addicts. In neurobiological theories, non-addictive drug consumption is …

All neuronal circuits are subject to neuromodulation. Modulatory effects on neuronal
processing and resulting behavioral changes are most commonly reported for higher order …

Although we understand how serotonin receptors function at the single-cell level, what role
different serotonin receptors play in regulating brain-wide activity and, in turn, human …

The brain serotonin systems participate in numerous aspects of reward processing, although
it remains elusive how exactly serotonin signals regulate neural computation and reward …

Reflecting one's mental self is a fundamental process for evaluating the personal relevance
of life events and for moral decision making and future envisioning. Although the …

This paper is a personal account on the discovery and characterization of the 5-HT 2C
receptor (first known as the 5-HT 1C receptor) over 30 years ago and how it translated into a …

Since its theoretical inception, psychopathy has been considered by philosophers,
clinicians, theorists, and empirical researchers to be substantially and critically explained by …

Currently, about 246 million people around the world have used an illicit drug. The reasons
for this use are multiple: eg to augment the sensation of pleasure or to reduce the withdrawal …