Glial cells were long considered end products of neural differentiation, specialized
supportive cells with an origin very different from that of neurons. New studies have shown …

The lining of the intestine is renewed at an extraordinary rate, outpacing all other tissues in
the vertebrate body. The renewal process is neatly organized in space, so that the whole …

Postmitotic neurons are produced from a pool of cycling progenitors in an orderly fashion
during development. Studies of cell-fate determination in the vertebrate retina have …

While the transmembrane protein Notch plays an important role in various aspects of
development, and diseases including tumors and neurological disorders, the intracellular …

Signals through the Notch receptors are used throughout development to control cellular
fate choices. Loss-and gain-of-function studies revealed both the pleiotropic action of the …

The molecular mechanisms mediating the retinogenic potential of multipotent retinal
progenitor cells (RPCs) are poorly defined. Prior to initiating retinogenesis, RPCs express a …

Notch signaling is an evolutionarily conserved pathway that regulates important biological
processes, such as cell proliferation, apoptosis, migration, self-renewal, and differentiation …

Notch signaling induced by canonical Notch ligands is critical for normal embryonic
development and tissue homeostasis through the regulation of a variety of cell fate decisions …

Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are
permitted to become neurons within domains defined by proneural gene expression …

The Notch signaling pathway regulates a diverse array of cell types and cellular processes
and is tightly regulated by ligand binding. Both canonical and noncanonical Notch ligands …