Over the past decade, great progress has been made in understanding the complexity of
adipose tissue biology and its role in metabolism. This includes new insights into the …

The discovery of leptin changed the view of adipose tissue from that of a passive vessel that
stores fat to that of a dynamic endocrine organ that actively regulates behaviour and …

Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …

The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

Adipose tissue and the liver play significant roles in the regulation of whole-body energy
homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient …

Leptin has emerged over the past 2 decades as a key hormone secreted by adipose tissue
that conveys information on energy stores. Leptin is considered an important regulator of …

Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …

Lipodystrophy syndromes are rare diseases originating from a generalized or partial loss of
adipose tissue. Adipose tissue dysfunction results from heterogeneous genetic or acquired …

Recombinant human leptin (metreleptin) reduces hepatic lipid content in patients with
lipodystrophy and overweight patients with non-alcoholic fatty liver disease and relative …

Remedies for the treatment of obesity date to Hippocrates, when patients with obesity were
directed to “reduce food and avoid drinking to fullness” and begin “running during the night.” …