Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …

The global burden of cancer is growing and a wide disparity in the incidence, malignancy
and mortality of different types of cancer between each sex has been demonstrated. The sex …

In this phase I/II clinical trial, we investigated the safety and efficacy of high doses of mb-IL21
ex vivo expanded donor-derived NK cells to decrease relapse in 25 patients with myeloid …

Importance Use of haploidentical (HAPLO) stem cell transplantation with posttransplant
cyclophosphamide is rapidly increasing in adults with hematologic cancers. However, its …

Donor-specific anti-HLA antibodies (DSAs) are a major cause of engraftment failure in
patients receiving haploidentical stem cell transplantation (HaploSCT). Effective treatments …

HLA-haploidentical hematopoietic stem cell transplantation is now one of the most
commonly employed alternative donor techniques, with most centers applying T-cell–replete …

Abstract Treatment options for newly diagnosed aplastic anemia (AA) patient includes
upfront allogeneic hematopoietic stem cell transplant (HSCT) or immunosuppressive …

Background Previous reports suggest a benefit associated with haploidentical donor
transplantation (HIDT) compared to matched sibling donor transplantation (MSDT) in certain …

Hematopoietic cell transplantation (HCT) has been successfully used to treat many
malignant and nonmalignant conditions. As supportive care, donor selection, and treatment …

Natural killer (NK) lymphocytes are an integral component of the innate immune system and
represent important effector cells in cancer immunotherapy, particularly in the control of …