Brain lipidomics: From functional landscape to clinical significance

JH Yoon, Y Seo, YS Jo, S Lee, E Cho… - Science …, 2022 - science.org
Lipids are crucial components of cellular function owing to their role in membrane formation,
intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid …

New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson's disease

R Gupta, S Kumari, A Senapati, RK Ambasta… - Ageing research …, 2023 - Elsevier
Parkinson's disease (PD) is characterized by the loss of neuronal cells, which leads to
synaptic dysfunction and cognitive defects. Despite the advancements in treatment …

Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

[HTML][HTML] Integrative multi-omics and systems bioinformatics in translational neuroscience: A data mining perspective

LM O'Connor, BA O'Connor, SB Lim, J Zeng… - Journal of …, 2023 - Elsevier
Bioinformatic analysis of large and complex omics datasets has become increasingly useful
in modern day biology by providing a great depth of information, with its application to …

Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine

I Agrawal, YS Lim, SY Ng, SC Ling - Translational Neurodegeneration, 2022 - Springer
Lipids, defined by low solubility in water and high solubility in nonpolar solvents, can be
classified into fatty acids, glycerolipids, glycerophospholipids, sphingolipids, and sterols …

Punicic acid and its role in the prevention of neurological disorders: A review

CM Guerra-Vázquez, M Martínez-Ávila… - Foods, 2022 - mdpi.com
Millions of people worldwide are affected by neurodegenerative diseases (NDs). NDs are
characterized by progressive damage and death of nerve cells accompanied by high levels …

Machine learning in Alzheimer's disease drug discovery and target identification

C Geng, ZB Wang, Y Tang - Ageing Research Reviews, 2023 - Elsevier
Alzheimer's disease (AD) stands as a formidable neurodegenerative ailment that poses a
substantial threat to the elderly population, with no known curative or disease-slowing drugs …

Lipidomic profiling study on neurobehavior toxicity in zebrafish treated with aflatoxin B1

Z Wang, X Li, T Wang, G Liao, J Gu, R Hou… - Science of The Total …, 2023 - Elsevier
Abstract Mycotoxin aflatoxin B1 (AFB1) has been proven to cause neurotoxicity, but its
potential interference with the normal function of brain tissue is not fully defined. As the …

Intestinal microbiota remodeling protects mice from western diet-induced brain inflammation and cognitive decline

PK Jena, T Setayesh, L Sheng, J Di Lucente, LW Jin… - Cells, 2022 - mdpi.com
It has been shown that the Western diet (WD) induces systemic inflammation and cognitive
decline. Moreover, probiotic supplementation and antibiotic treatment reduce diet-induced …

Alterations of oligodendrocyte and myelin energy metabolism in multiple sclerosis

E López-Muguruza, C Matute - International journal of molecular sciences, 2023 - mdpi.com
Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system
(CNS), characterized by demyelination and neurodegeneration. Oligodendrocytes play a …