Brain lipidomics: From functional landscape to clinical significance
JH Yoon, Y Seo, YS Jo, S Lee, E Cho… - Science …, 2022 - science.org
Lipids are crucial components of cellular function owing to their role in membrane formation,
intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid …
intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid …
New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson's disease
Parkinson's disease (PD) is characterized by the loss of neuronal cells, which leads to
synaptic dysfunction and cognitive defects. Despite the advancements in treatment …
synaptic dysfunction and cognitive defects. Despite the advancements in treatment …
Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease
M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
[HTML][HTML] Integrative multi-omics and systems bioinformatics in translational neuroscience: A data mining perspective
Bioinformatic analysis of large and complex omics datasets has become increasingly useful
in modern day biology by providing a great depth of information, with its application to …
in modern day biology by providing a great depth of information, with its application to …
Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine
Lipids, defined by low solubility in water and high solubility in nonpolar solvents, can be
classified into fatty acids, glycerolipids, glycerophospholipids, sphingolipids, and sterols …
classified into fatty acids, glycerolipids, glycerophospholipids, sphingolipids, and sterols …
Punicic acid and its role in the prevention of neurological disorders: A review
CM Guerra-Vázquez, M Martínez-Ávila… - Foods, 2022 - mdpi.com
Millions of people worldwide are affected by neurodegenerative diseases (NDs). NDs are
characterized by progressive damage and death of nerve cells accompanied by high levels …
characterized by progressive damage and death of nerve cells accompanied by high levels …
Machine learning in Alzheimer's disease drug discovery and target identification
C Geng, ZB Wang, Y Tang - Ageing Research Reviews, 2023 - Elsevier
Alzheimer's disease (AD) stands as a formidable neurodegenerative ailment that poses a
substantial threat to the elderly population, with no known curative or disease-slowing drugs …
substantial threat to the elderly population, with no known curative or disease-slowing drugs …
Lipidomic profiling study on neurobehavior toxicity in zebrafish treated with aflatoxin B1
Z Wang, X Li, T Wang, G Liao, J Gu, R Hou… - Science of The Total …, 2023 - Elsevier
Abstract Mycotoxin aflatoxin B1 (AFB1) has been proven to cause neurotoxicity, but its
potential interference with the normal function of brain tissue is not fully defined. As the …
potential interference with the normal function of brain tissue is not fully defined. As the …
Intestinal microbiota remodeling protects mice from western diet-induced brain inflammation and cognitive decline
It has been shown that the Western diet (WD) induces systemic inflammation and cognitive
decline. Moreover, probiotic supplementation and antibiotic treatment reduce diet-induced …
decline. Moreover, probiotic supplementation and antibiotic treatment reduce diet-induced …
Alterations of oligodendrocyte and myelin energy metabolism in multiple sclerosis
E López-Muguruza, C Matute - International journal of molecular sciences, 2023 - mdpi.com
Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system
(CNS), characterized by demyelination and neurodegeneration. Oligodendrocytes play a …
(CNS), characterized by demyelination and neurodegeneration. Oligodendrocytes play a …