Subclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer
evolution studies, providing insight into the clonality and relative ordering of mutations and …

Single-cell sequencing (SCS) has impacted many areas of cancer research and improved
our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and …

We use deep transfer learning to quantify histopathological patterns across 17,355
hematoxylin and eosin-stained histopathology slide images from 28 cancer types and …

Cancer develops through a process of somatic evolution,. Sequencing data from a single
biopsy represent a snapshot of this process that can reveal the timing of specific genomic …

Transcript alterations often result from somatic changes in cancer genomes. Various forms of
RNA alterations have been described in cancer, including overexpression, altered splicing …

Metastatic cancer is a major cause of death and remains largely incurable. A better
understanding of metastasis is therefore desperately needed to improve prognosis for late …

Single-cell barcoding technologies enable genome sequencing of thousands of individual
cells in parallel, but with extremely low sequencing coverage (< 0.05×) per cell. While the …

Limited clinical activity has been seen in osteosarcoma (OS) patients treated with immune
checkpoint inhibitors (ICI). To gain insights into the immunogenic potential of these tumors …

Advanced and metastatic tumors with complex treatment histories drive cancer mortality.
Here we describe the POG570 cohort, a comprehensive whole-genome, transcriptome and …

Copy-number aberrations (CNAs) and whole-genome duplications (WGDs) are frequent
somatic mutations in cancer but their quantification from DNA sequencing of bulk tumor …