Long noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200
nucleotides (nt) without coding potential. Over the past decade, tens of thousands of novel …

Viruses must co-opt the cellular translation machinery to produce progeny virions.
Eukaryotic viruses have evolved a variety of ways to manipulate the cellular translation …

Although genomic analyses predict many noncanonical open reading frames (ORFs) in the
human genome, it is unclear whether they encode biologically active proteins. Here we …

Short ORFs (sORFs), that is, occurrences of a start and stop codon within 100 codons or
less, can be found in organisms of all domains of life, outnumbering annotated protein …

Abstract Ribosome profiling (Ribo-Seq) has proven transformative for our understanding of
the human genome and proteome by illuminating thousands of noncanonical sites of …

Proteogenomic identification of translated small open reading frames has revealed
thousands of previously unannotated, largely uncharacterized microproteins, or …

Discovering the gene expression signature associated with a cellular state is one of the
basic quests in majority of biological studies. For most of the clinical and cellular …

During the past decade, there has been a rapidly increased appreciation of the role of
translation as a key regulatory node in gene expression. Thereby, the development of …

An increasing amount of studies integrate mRNA sequencing data into MS-based
proteomics to complement the translation product search space. However, several factors …

The protein-level translational status and function of many alternative splicing events remain
poorly understood. We use an RNA sequencing (RNA-seq)-guided proteomics method to …