Erdheim-Chester disease (ECD) is a rare histiocytosis that was recently recognized as a
neoplastic disorder owing to the discovery of recurrent activating MAPK (RAS-RAF-MEK …

Histiocytoses are heterogeneous hematopoietic diseases characterized by the accumulation
of CD68 (+) cells with various admixed inflammatory infiltrates. The identification of the …

Langerhans cell histiocytosis (LCH) can affect children and adults with a wide variety of
clinical manifestations, including unifocal, single-system multifocal, single-system pulmonary …

Histiocytic neoplasms are rare hematologic disorders accounting for less than 1% of cancers
of the soft tissue and lymph nodes. Clinical presentation and prognosis of these disorders …

Erdheim-Chester disease (ECD) is a rare, multisystemic, inflammatory, non–Langerhans cell
histiocytic neoplasm. The discovery of recurrent and somatic mutations in the mitogen …

Pulmonary Langerhans cell (LC) histiocytosis (PLCH) has unknown cause and is a rare
neoplastic disorder characterized by the infiltration of lungs and various organs by bone …

Histiocytic disorders are an exceptionally rare group of diseases with diverse manifestations
and a paucity of approved treatments, thereby leading to various challenges in their …

Erdheim–Chester disease (ECD) is a rare but increasingly recognized multi-system
disorder. Its diagnosis and treatment require integration of clinical information, imaging …

Background Juvenile xanthogranuloma (JXG) is the most common type of non-Langerhans
cell histiocytosis whose cell of origin, etiology and pathogenesis are not fully understood …

Histiocytosis is a rare inflammatory process characterized by pathologic infiltration and
accumulation of cells derived from the monocytic lineage in normal tissue. It encompasses …