Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

There is nervous control of the heart by ATP as a cotransmitter in sympathetic,
parasympathetic, and sensory-motor nerves, as well as in intracardiac neurons. Centers in …

Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised.
P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular …

Purinergic P2X7 receptor, a nonselective cation channel, is highly expressed in immune
cells as well as cardiac smooth muscle cells and endothelial cells. Its activation exhibits to …

Myocarditis is an important cause of heart failure in young patients. Autoreactive, most often,
infection‐triggered CD4+ T cells were confirmed to be critical for myocarditis induction. Due …

Continuous remodeling of the heart can result in adverse events such as reduced
myocardial function and heart failure. Available evidence indicates that ferroptosis is a key …

The incidence and prevalence of diabetes mellitus (DM) are increasing worldwide, and the
resulting cardiac complications are the leading cause of death. Among these complications …

Objective: Extracellular ATP is elevated in hypertensive mice and humans and may trigger
immune activation through the purinergic receptor P2X7 (P2RX7) causing interleukin-1β …

Dilated cardiomyopathy (DCM) is a non-ischemic cardiomyopathy involving one or more
underlying etiologies. It is characterized by structural and functional dysfunction of the …

The P2X7 purinergic receptor, a calcium permeable cationic channel, is activated by
extracellular ATP. Most studies show that P2X7 receptor plays an important role in the …