Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …

Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …

Mood disorders, also often referred to as affective disorders, are a group of psychiatric
illnesses that severely impact mood and its related functions. The high medical expenditures …

Despite many advances in management and housing of dairy calves, 1 in 10 US dairy
heifers die before weaning. A better understanding of the internal and external stimuli that …

Pro-opiomelanocortin (POMC) is the archetypal polypeptide precursor of hormones and
neuropeptides. In this review, we examine the variability in the individual peptides produced …

Evidence is accumulating regarding the importance of circadian core oscillators, several
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …

The pronounced daily variation in the release of adrenal hormones has been at the heart of
the deciphering and understanding of the circadian timing system. Indeed, the first …

Chronic glucocorticoid (GC) treatment represents a widely-prescribed therapy for several
diseases in consideration of both anti-inflammatory and immunosuppressive activity but, if …

Virtually every eukaryotic cell has an endogenous circadian clock and a biological sex.
These cell-based clocks have been conceptualized as oscillators whose phase can be reset …

Intermittent fasting has become an increasingly popular strategy in losing weight and
associated reduction in obesity-related medical complications. Overwhelming studies …