Although the phosphorus atom is found in a variety of oxidation states, most of the
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …

The opportunistic apicomplexan parasite Toxoplasma gondii is the etiologic agent for
toxoplasmosis, which can infect a widespread range of hosts, particularly humans and warm …

Trypanosoma cruzi and Leishmania spp. are protozoa of the Trypanosomatidae family,
being the etiological agents of two widespread parasitic diseases, Chagas disease and …

Phosphonates and bisphosphonates have proven their pharmacological utility as inhibitors
of enzymes that metabolize phosphate and pyrophosphate substrates. The blockbuster …

Neglected tropical diseases such as Chagas disease and leishmaniasis affect millions of
people around the world. Both diseases affect various parts of the globe and drugs …

We have previously shown that prenyl and aliphatic triazoles are interesting motifs to
prepare new chemical entities for antiparasitic and antituberculosis drug development. In …

Human American trypanosomiasis, commonly called Chagas disease, is one of the most
neglected illnesses in the world and remains one of the most prevalent chronic infectious …

Substituted hydroxymethylenebisphosphonic acid derivatives–either as dronic acids or their
dronate sodium salts, are important pharmaceuticals in the treatment of diseases arising …

Introduction: Toxoplasma gondii is an opportunistic protozoan parasite responsible for
toxoplasmosis. T. gondii is able to infect a wide range of hosts, particularly humans and …

As part of our efforts aimed at searching for new antiparasitic agents, 2-alkylmercaptoethyl-1,
1-bisphosphonate derivatives were synthesized and evaluated against Trypanosoma cruzi …