[HTML][HTML] Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective
Y Yang, S Li, Y Wang, Y Zhao, Q Li - Signal transduction and targeted …, 2022 - nature.com
Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …
[HTML][HTML] Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications
SJ Serrano-Gomez, M Maziveyi, SK Alahari - Molecular cancer, 2016 - Springer
The epithelial to mesenchymal transition (EMT) is a biological process in which a non-motile
epithelial cell changes to a mesenchymal phenotype with invasive capacities. This …
epithelial cell changes to a mesenchymal phenotype with invasive capacities. This …
Signaling mechanisms of the epithelial-mesenchymal transition
DM Gonzalez, D Medici - Science signaling, 2014 - science.org
The epithelial-mesenchymal transition (EMT) is an essential mechanism in embryonic
development and tissue repair. EMT also contributes to the progression of disease …
development and tissue repair. EMT also contributes to the progression of disease …
[HTML][HTML] New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies
Numerous cancers express platelet-derived growth factors (PDGFs) and PDGF receptors
(PDGFRs). By directly stimulating tumour cells in an autocrine manner or by stimulating …
(PDGFRs). By directly stimulating tumour cells in an autocrine manner or by stimulating …
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
W Yang, Y Xia, H Ji, Y Zheng, J Liang, W Huang, X Gao… - Nature, 2011 - nature.com
The embryonic pyruvate kinase M2 (PKM2) isoform is highly expressed in human cancer. In
contrast to the established role of PKM2 in aerobic glycolysis or the Warburg effect,,, its non …
contrast to the established role of PKM2 in aerobic glycolysis or the Warburg effect,,, its non …
MALAT-1, a novel noncoding RNA, and thymosin β4 predict metastasis and survival in early-stage non-small cell lung cancer
P Ji, S Diederichs, W Wang, S Böing, R Metzger… - Oncogene, 2003 - nature.com
Early-stage non-small cell lung cancer (NSCLC) can be cured by surgical resection, but a
substantial fraction of patients ultimately dies due to distant metastasis. In this study, we …
substantial fraction of patients ultimately dies due to distant metastasis. In this study, we …
The role of focal-adhesion kinase in cancer—a new therapeutic opportunity
GW McLean, NO Carragher, E Avizienyte… - Nature Reviews …, 2005 - nature.com
Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell
proliferation, cell survival and cell migration. Given that the development of malignancy is …
proliferation, cell survival and cell migration. Given that the development of malignancy is …
The antitumor activities of flavonoids
C Kanadaswami, LT Lee, PPH Lee, JJ Hwang, FC Ke… - In vivo, 2005 - iv.iiarjournals.org
The flavonoids are polyphenolic compounds found as integral components of the human
diet. They are universally present as constituents of flowering plants, particularly of food …
diet. They are universally present as constituents of flowering plants, particularly of food …
[HTML][HTML] Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion
EGF receptor (EGFR) overexpression correlates with metastasis in a variety of carcinomas,
but the underlying mechanisms are poorly understood. We demonstrated that EGF disrupted …
but the underlying mechanisms are poorly understood. We demonstrated that EGF disrupted …
Silencing EGFR-upregulated expression of CD55 and CD59 activates the complement system and sensitizes lung cancer to checkpoint blockade
The complement system is a critical immune component, yet its role in tumor immune
evasion and CD8+ T cell activation is not clearly defined. Here, we demonstrate that …
evasion and CD8+ T cell activation is not clearly defined. Here, we demonstrate that …