The human Y chromosome is intriguing not only because it harbours the master-switch gene
that determines gender but also because of its unusual evolutionary history. The Y …

Sex chromosomes have many unusual features relative to autosomes. Y (or W)
chromosomes lack genetic recombination, are male-(female-) limited, and show an …

Small noncoding piRNAs act as sequence-specific guides to repress complementary targets
in Metazoa. Prior studies in Drosophila ovaries have demonstrated the function of the piRNA …

The heterochromatic state of the Drosophila Y chromosome has made the cloning and
identification of Y-linked genes a challenging process. Here, we report application of a …

The molecular identity and function of the Drosophila melanogaster Y-linked fertility factors
have long eluded researchers. Although the D. melanogaster genome sequence was …

In many species, the Y (or W) chromosome carries relatively few functional genes. This
observation motivates the null hypothesis that the Y will be a minor contributor to genetic …

This review is based on a thorough description of the structure and sequence organization
of tandemly organized repetitive DNA sequence families in the human genome; it is aimed …

Three recent findings are making a deep impact on our understanding of the Drosophila Y.
First, the sequencing of the Drosophila genome and the development of proper …

We report a genome-wide search of Y-linked genes in Drosophila pseudoobscura. All six
identifiable orthologs of the D. melanogaster Y-linked genes have autosomal inheritance in …

The purpose of this chapter in FlyBook is to acquaint the reader with the Drosophila genome
and the ways in which it can be altered by mutation. Much of what follows will be familiar to …