Peptide design and self-assembly into targeted nanostructure and functional materials

NJ Sinha, MG Langenstein, DJ Pochan… - Chemical …, 2021 - ACS Publications
Peptides have been extensively utilized to construct nanomaterials that display targeted
structure through hierarchical assembly. The self-assembly of both rationally designed …

Polyelectrolyte complex coacervates: Recent developments and new frontiers

AM Rumyantsev, NE Jackson… - Annual Review of …, 2021 - annualreviews.org
Polyelectrolyte complex coacervates represent a wide class of materials with applications
ranging from coatings and adhesives to pharmaceutical technologies. They also underpin …

Driving force and pathway in polyelectrolyte complex coacervation

S Chen, ZG Wang - … of the National Academy of Sciences, 2022 - National Acad Sciences
There is notable discrepancy between experiments and coarse-grained model studies
regarding the thermodynamic driving force in polyelectrolyte complex coacervation …

Complete phase diagram for liquid–liquid phase separation of intrinsically disordered proteins

J McCarty, KT Delaney, SPO Danielsen… - The journal of …, 2019 - ACS Publications
A number of intrinsically disordered proteins have been shown to self-assemble via liquid–
liquid phase separation into protein-rich and dilute phases. The resulting coacervates can …

Comparative roles of charge, π, and hydrophobic interactions in sequence-dependent phase separation of intrinsically disordered proteins

S Das, YH Lin, RM Vernon… - Proceedings of the …, 2020 - National Acad Sciences
Endeavoring toward a transferable, predictive coarse-grained explicit-chain model for
biomolecular condensates underlain by liquid–liquid phase separation (LLPS) of proteins …

Dehydration entropy drives liquid-liquid phase separation by molecular crowding

S Park, R Barnes, Y Lin, B Jeon, S Najafi… - Communications …, 2020 - nature.com
Complex coacervation driven liquid-liquid phase separation (LLPS) of biopolymers has
been attracting attention as a novel phase in living cells. Studies of LLPS in this context are …

The protein folding problem: the role of theory

R Nassar, GL Dignon, RM Razban, KA Dill - Journal of molecular biology, 2021 - Elsevier
The protein folding problem was first articulated as question of how order arose from
disorder in proteins: How did the various native structures of proteins arise from interatomic …

100th anniversary of macromolecular science viewpoint: Opportunities in the physics of sequence-defined polymers

SL Perry, CE Sing - ACS Macro Letters, 2020 - ACS Publications
Polymer science has been driven by ever-increasing molecular complexity, as polymer
synthesis expands an already-vast palette of chemical and architectural parameter space …

Protein encapsulation using complex coacervates: what nature has to teach us

WC Blocher McTigue, SL Perry - Small, 2020 - Wiley Online Library
Protein encapsulation is a growing area of interest, particularly in the fields of food science
and medicine. The sequestration of protein cargoes is achieved using a variety of methods …

Sequence‐tunable phase behavior and intrinsic fluorescence in dynamically interacting peptides

D Sementa, D Dave, RS Fisher, T Wang… - Angewandte …, 2023 - Wiley Online Library
A conceptual framework towards understanding biological condensed phases is emerging,
derived from biological, biomimetic, and synthetic sequences. However, de novo peptide …