Abstract Treatment of tuberculosis (TB) involves the administration of anti-mycobacterial
drugs for several months. The emergence of drug-resistant strains of Mycobacterium …

The adaptive immune response mediated by T cells is critical for control of Mycobacterium
tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens …

IL-17A–producing γδ T cells in mice consist primarily of Vγ6+ tissue-resident cells and Vγ4+
circulating cells. How these γδ T cell subsets are regulated during homeostasis and cancer …

The emergence of multiantibiotic-resistant bacteria, often referred to as superbugs, is
leading to infections that are increasingly difficult to treat. Further, bacteria have evolved …

Abstract Interleukin-17 (IL-17), IL-21, IL-22 and IL-23 can be grouped as T helper 17 (Th17)-
related cytokines because they are either produced by Th17/Th22 cells or involved in their …

The suppressor of cytokine signalling‐3 (SOCS 3) is well known as a feedback inhibitor of
the Janus kinases‐signal transducer and activator of transcription 3 (JAK/STAT 3) signalling …

Objectives Immune checkpoint pathways regulate optimal host immune responses against
transformed cells, induce immunological memory, and limit tissue pathology. Conversely …

The classical paradigm of tuberculosis (TB) immunity, with a central protective role for Th1
responses and IFN-γ-stimulated cellular responses, has been challenged by unsatisfactory …

The discovery of new gain-of-function mutations in STAT3, as well as new studies among
patients with loss-of-function mutations, expand the understanding of the pathophysiology of …

Antibiotic-resistant bacterial pathogens are increasingly implicated in hospital-and
community-acquired infections. Recent advances in monoclonal antibody (mAb) production …