Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology
Nonalcoholic fatty liver disease (NAFLD) affects around a quarter of the global population,
paralleling worldwide increases in obesity and metabolic syndrome. NAFLD arises in the …
paralleling worldwide increases in obesity and metabolic syndrome. NAFLD arises in the …
[HTML][HTML] Type I interferons in infectious disease
F McNab, K Mayer-Barber, A Sher, A Wack… - Nature Reviews …, 2015 - nature.com
Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …
Interferon-λ: immune functions at barrier surfaces and beyond
When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …
Interferome v2. 0: an updated database of annotated interferon-regulated genes
I Rusinova, S Forster, S Yu, A Kannan… - Nucleic acids …, 2012 - academic.oup.com
Abstract Interferome v2. 0 (http://interferome. its. monash. edu. au/interferome/) is an update
of an earlier version of the Interferome DB published in the 2009 NAR database edition …
of an earlier version of the Interferome DB published in the 2009 NAR database edition …
Guarding the frontiers: the biology of type III interferons
A Wack, E Terczyńska-Dyla, R Hartmann - Nature immunology, 2015 - nature.com
Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …
Differential activation of the transcription factor IRF1 underlies the distinct immune responses elicited by type I and type III interferons
Type I and III interferons (IFNs) activate similar downstream signaling cascades, but unlike
type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we …
type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we …
The role of structure in the biology of interferon signaling
MR Walter - Frontiers in immunology, 2020 - frontiersin.org
Interferons (IFNs) are a family of cytokines with the unique ability to induce cell intrinsic
programs that enhance resistance to viral infection. Induction of an antiviral state at the cell …
programs that enhance resistance to viral infection. Induction of an antiviral state at the cell …
Regulation and functions of the IL-10 family of cytokines in inflammation and disease
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-
26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family …
26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family …
Immune responses and immunopathology in acute and chronic viral hepatitis
Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …