Tau post-translational modifications: dynamic transformers of tau function, degradation, and aggregation
C Alquezar, S Arya, AW Kao - Frontiers in neurology, 2021 - frontiersin.org
Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …
protein function and contributing to neurodegeneration. The explosion of information on …
Protein language: post-translational modifications talking to each other
Post-translational modifications (PTMs) are at the heart of many cellular signaling events.
Apart from a single regulatory PTM, there are also PTMs that function in orchestrated …
Apart from a single regulatory PTM, there are also PTMs that function in orchestrated …
PP2A as a master regulator of the cell cycle
N Wlodarchak, Y Xing - Critical reviews in biochemistry and …, 2016 - Taylor & Francis
Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
Linking post-translational modifications and protein turnover by site-resolved protein turnover profiling
Proteome-wide measurements of protein turnover have largely ignored the impact of post-
translational modifications (PTMs). To address this gap, we employ stable isotope labeling …
translational modifications (PTMs). To address this gap, we employ stable isotope labeling …
Expanding the ubiquitin code through post‐translational modification
Ubiquitylation is among the most prevalent post‐translational modifications (PTM s) and
regulates numerous cellular functions. Interestingly, ubiquitin (Ub) can be itself modified by …
regulates numerous cellular functions. Interestingly, ubiquitin (Ub) can be itself modified by …
Global and site-specific effect of phosphorylation on protein turnover
To date, the effects of specific modification types and sites on protein lifetime have not been
systematically illustrated. Here, we describe a proteomic method, DeltaSILAC, to …
systematically illustrated. Here, we describe a proteomic method, DeltaSILAC, to …
Protein degradation on the global scale
Protein degradation occurs through proteasomal, endosomal, and lysosomal pathways.
Technological advancements have allowed for the determination of protein copy numbers …
Technological advancements have allowed for the determination of protein copy numbers …
Crosstalk between phosphorylation and O‐Glc NA cylation: friend or foe
A wide variety of protein post‐translational modifications (PTM s) decorate cellular proteins,
regulating their structure, interactions and ultimately their function. The density of co …
regulating their structure, interactions and ultimately their function. The density of co …
Peptide level turnover measurements enable the study of proteoform dynamics
The coordination of protein synthesis and degradation regulating protein abundance is a
fundamental process in cellular homeostasis. Today, mass spectrometry-based …
fundamental process in cellular homeostasis. Today, mass spectrometry-based …
Squalene monooxygenase: a journey to the heart of cholesterol synthesis
Squalene monooxygenase (SM) is a vital sterol synthesis enzyme across eukaryotic life. In
yeast, it is a therapeutic target for treating certain fungal infections, and in mammals it is a …
yeast, it is a therapeutic target for treating certain fungal infections, and in mammals it is a …