Multicellular spheroids are three dimensional in vitro microscale tissue analogs. The current
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …

Determining the migratory and invasive capacity of tumor and stromal cells and clarifying the
underlying mechanisms is most relevant for novel strategies in cancer diagnosis, prognosis …

Many types of mammalian cells can aggregate and differentiate into 3‐D multicellular
spheroids when cultured in suspension or a nonadhesive environment. Compared to …

Over the past few years, establishment and adaptation of cell-based assays for drug
development and testing has become an important topic in high-throughput screening …

Purpose: To give a state-of-the-art overview on the promise of three-dimensional (3-D)
culture systems for anticancer drug development, with particular emphasis on multicellular …

Evaluation of cancer therapeutics by utilizing 3D tumor models, before clinical studies, could
be more advantageous than conventional 2D tumor models (monolayer cultures). The 3D …

The development of vessel-like structures in vitro to mimic as well as to realize the possibility
of tissue-engineered small vascular networks presents a major challenge to cell biologists …

Self-assembled structures primarily arise through enzyme-regulated phenomena in nature
under persistent conditions. Enzymatic reactions are one of the main biological processes …

Abstract Three-dimensional (3D) tissue constructs consisting of human cells have opened a
new avenue for tissue engineering, pharmaceutical and pathophysiological applications …

Abstract Three-dimensional (3D) organoids have shown advantages in cell culture over
traditional two-dimensional (2D) culture, and have great potential in various applications of …