Glioma stem-like cells and metabolism: potential for novel therapeutic strategies

A Harland, X Liu, M Ghirardello, MC Galan… - Frontiers in …, 2021 - frontiersin.org
Glioma stem-like cells (GSCs) were first described as a population which may in part be
resistant to traditional chemotherapeutic therapies and responsible for tumour regrowth …

Recent advances in the use of lipid-based nanoparticles against glioblastoma multiforme

B Ortega-Berlanga, C Gonzalez… - Archivum Immunologiae et …, 2021 - Springer
Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults.
Although the overall incidence is less than 10 per 100,000 individuals, its poor prognosis …

TOOme: a novel computational framework to infer cancer tissue-of-origin by integrating both gene mutation and expression

B He, J Lang, B Wang, X Liu, Q Lu, J He… - … in bioengineering and …, 2020 - frontiersin.org
Metastatic cancers require further diagnosis to determine their primary tumor sites. However,
the tissue-of-origin for around 5% tumors could not be identified by routine medical …

[HTML][HTML] A machine learning framework to trace tumor tissue-of-origin of 13 types of cancer based on DNA somatic mutation

B He, C Dai, J Lang, P Bing, G Tian, B Wang… - Biochimica et Biophysica …, 2020 - Elsevier
Carcinoma of unknown primary (CUP), defined as metastatic cancers with unknown cancer
origin, occurs in 3‐5 per 100 cancer patients in the United States. Heterogeneity and …

Isocitrate dehydrogenase (IDH) 1/2 mutations as prognostic markers in patients with glioblastomas

JR Chen, Y Yao, HZ Xu, ZY Qin - Medicine, 2016 - journals.lww.com
Isocitrate Dehydrogenase (IDH)1/2 Mutations as Prognostic Ma... : Medicine Isocitrate
Dehydrogenase (IDH)1/2 Mutations as Prognostic Markers in Patients With Glioblastomas …

A potent blood–brain barrier-permeable mutant IDH1 inhibitor suppresses the growth of glioblastoma with IDH1 mutation in a patient-derived orthotopic xenograft …

Y Machida, M Nakagawa, H Matsunaga… - Molecular cancer …, 2020 - AACR
Gliomas are the second most common primary brain tumors in adults. They are treated with
combination therapies, including surgery, radiotherapy, and chemotherapy. There are …

Survival in patients with glioblastoma at a first progression does not correlate with isocitrate dehydrogenase (IDH)1 gene mutation status

Y Tabei, K Kobayashi, K Saito, S Shimizu… - Japanese journal of …, 2021 - academic.oup.com
Backgrounds Mutations in the isocitrate dehydrogenase (IDH) 1 gene are favourable
prognostic factors in newly diagnosed diffuse gliomas, whereas it remains controversial in …

Short‐echo three‐dimensional H‐1 MR spectroscopic imaging of patients with glioma at 7 Tesla for characterization of differences in metabolite levels

Y Li, P Larson, AP Chen, JM Lupo… - Journal of Magnetic …, 2015 - Wiley Online Library
Background The purpose of this study was to evaluate the feasibility of using a short echo
time, three‐dimensional H‐1 magnetic resonance spectroscopic imaging (MRSI) sequence …

Imaging tumor metabolism using in vivo magnetic resonance spectroscopy

Y Li, I Park, SJ Nelson - The Cancer Journal, 2015 - journals.lww.com
Magnetic resonance spectroscopy (MRS) is a powerful tool for noninvasively investigating
normal and abnormal metabolism. When used in combination with imaging strategies …

EGFR, p53, IDH-1 and MDM2 immunohistochemical analysis in glioblastoma: therapeutic and prognostic correlation

RM Montgomery, LS Queiroz, F Rogerio - Arquivos de neuro …, 2015 - SciELO Brasil
We studied 36 glioblastoma cases at HC-UNICAMP from 2008 to 2012 and classified the
immunohistochemical distribution of the wild-type epidermal growth factor receptor (EGFR) …