Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours
Background In this first-in-human, Phase 1 study of a microRNA-based cancer therapy, the
recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of microRNA-34a (miR …
recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of microRNA-34a (miR …
Interactions between short and long noncoding RNAs
I Ulitsky - FEBS letters, 2018 - Wiley Online Library
It is now evident that noncoding RNAs play key roles in regulatory networks determining cell
fate and behavior, in a myriad of different conditions, and across all species. Among these …
fate and behavior, in a myriad of different conditions, and across all species. Among these …
MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways
BN Chau, C Xin, J Hartner, S Ren… - Science translational …, 2012 - science.org
Scarring of the kidney is a major public health concern, directly promoting loss of kidney
function. To understand the role of microRNA (miRNA) in the progression of kidney scarring …
function. To understand the role of microRNA (miRNA) in the progression of kidney scarring …
hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1
The structure of messenger RNA is important for post-transcriptional regulation, mainly
because it affects binding of trans-acting factors. However, little is known about the in vivo …
because it affects binding of trans-acting factors. However, little is known about the in vivo …
MicroRNA-9 inhibition of cell proliferation and identification of novel miR-9 targets by transcriptome profiling in breast cancer cells
Although underexpression of miR-9 in cancer cells is reported in many cancer types, it is
currently difficult to classify miR-9 as a tumor suppressor or an oncomir. We demonstrate that …
currently difficult to classify miR-9 as a tumor suppressor or an oncomir. We demonstrate that …
mir-34b/c and mir-449a/b/c are required for spermatogenesis, but not for the first cleavage division in mice
Mammalian sperm are carriers of not only the paternal genome, but also the paternal
epigenome in the forms of DNA methylation, retained histones and noncoding RNAs …
epigenome in the forms of DNA methylation, retained histones and noncoding RNAs …
Altered lymphopoiesis and immunodeficiency in miR-142 null mice
MicroRNAs (miRNAs) are a class of powerful posttranscriptional regulators implicated in the
control of diverse biological processes, including regulation of hematopoiesis and the …
control of diverse biological processes, including regulation of hematopoiesis and the …
MicroRNA profiling of diverse endothelial cell types
MN McCall, OA Kent, J Yu, K Fox-Talbot… - BMC medical …, 2011 - Springer
Background MicroRNAs are~ 22-nt long regulatory RNAs that serve as critical modulators of
post-transcriptional gene regulation. The diversity of miRNAs in endothelial cells (ECs) and …
post-transcriptional gene regulation. The diversity of miRNAs in endothelial cells (ECs) and …
An overview of microRNA methods: expression profiling and target identification
MicroRNAs (miRNAs) are small, single-stranded RNA molecules encoded by genes that are
transcribed from DNA but not translated into protein (noncoding RNA). The ability of miRNA …
transcribed from DNA but not translated into protein (noncoding RNA). The ability of miRNA …
NF-κB signaling relieves negative regulation by miR-194 in hepatocellular carcinoma by suppressing the transcription factor HNF-1α
Constitutive activation of the proinflammatory transcription factor nuclear factor κB (NF-κB)
plays an important role in progression of hepatocellular carcinoma (HCC). Emerging …
plays an important role in progression of hepatocellular carcinoma (HCC). Emerging …