G protein-coupled receptors (GPCRs) are privileged structural scaffolds in biology that have
the versatility to regulate diverse physiological processes. Interestingly, many GPCR ligands …

In classical G-protein-coupled receptor (GPCR) activation, GPCRs couple to a variety of
heterotrimeric G proteins on the membrane and then activate downstream signaling …

Summary" Biased" G protein-coupled receptor (GPCR) agonists preferentially activate
pathways mediated by G proteins or β-arrestins. Here, we use double electron-electron …

Drug discovery targeting G protein-coupled receptors (GPCRs) is no longer limited to
seeking agonists or antagonists to stimulate or block cellular responses associated with a …

Biased agonists of G protein–coupled receptors (GPCRs) preferentially activate a subset of
downstream signaling pathways. In this work, we present crystal structures of angiotensin II …

Abstract Seven-transmembrane receptors (7TMRs; also known as G protein-coupled
receptors) are the largest class of receptors in the human genome and are common targets …

G protein coupled receptors have historically been one of the most druggable classes of
cellular proteins. The members of this large receptor gene family couple to primary effectors …

Upon their discovery, β-arrestins 1 and 2 were named for their capacity to sterically hinder
the G protein coupling of agonist-activated seven-transmembrane receptors, ultimately …

The angiotensin II (AngII) type 1 receptor (AT1R) is a critical regulator of cardiovascular and
renal function and is an important model for studies of G-protein-coupled receptor (GPCR) …

It is useful to consider seven transmembrane receptors (7TMRs) as disordered proteins able
to allosterically respond to a number of binding partners. Considering 7TMRs as allosteric …