[HTML][HTML] An emerging tumor invasion mechanism about the collective cell migration

Y Yang, H Zheng, Y Zhan, S Fan - American journal of translational …, 2019 - ncbi.nlm.nih.gov
Traditionally, the metastasis has been detected in the late stage of the cancer, which mostly
leads to death. The classical opinion about tumor metastasis is that tumor cell migration …

Bridging from single to collective cell migration: A review of models and links to experiments

A Buttenschön, L Edelstein-Keshet - PLoS computational biology, 2020 - journals.plos.org
Mathematical and computational models can assist in gaining an understanding of cell
behavior at many levels of organization. Here, we review models in the literature that focus …

Theory of mechanochemical patterning and optimal migration in cell monolayers

D Boocock, N Hino, N Ruzickova, T Hirashima… - Nature physics, 2021 - nature.com
Collective cell migration offers a rich field of study for non-equilibrium physics and cellular
biology, revealing phenomena such as glassy dynamics, pattern formation and active …

[HTML][HTML] MARK2 regulates directed cell migration through modulation of myosin II contractility and focal adhesion organization

AM Pasapera, SM Heissler, M Eto, Y Nishimura… - Current Biology, 2022 - cell.com
Cancer cell migration during metastasis is mediated by a highly polarized cytoskeleton.
MARK2 and its invertebrate homolog Par1B are kinases that regulate the microtubule …

Implementing computational modeling in tissue engineering: where disciplines meet

JN Post, S Loerakker, RMH Merks… - Tissue Engineering Part …, 2022 - liebertpub.com
In recent years, the mathematical and computational sciences have developed novel
methodologies and insights that can aid in designing advanced bioreactors, microfluidic …

Effects of surface patterning and topography on the cellular functions of tissue engineered scaffolds with special reference to 3D bioprinting

J Adhikari, A Roy, A Chanda, DA Gouripriya… - Biomaterials …, 2023 - pubs.rsc.org
The extracellular matrix (ECM) of the tissue organ exhibits a topography from the nano to
micrometer range, and the design of scaffolds has been inspired by the host environment …

Effect of geometric curvature on collective cell migration in tortuous microchannel devices

MB Mazalan, MAB Ramlan, JH Shin, T Ohashi - Micromachines, 2020 - mdpi.com
Collective cell migration is an essential phenomenon in many naturally occurring
pathophysiological processes, as well as in tissue engineering applications. Cells in tissues …

Multicellular mechanochemical hybrid cellular Potts model of tissue formation during epithelial‐mesenchymal transition

SU Hirway, CA Lemmon… - … and Systems Oncology, 2021 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is the transdifferentiation of epithelial cells to a
mesenchymal phenotype, in which cells lose epithelial‐like cell–cell adhesions and gain …

Quantitative imaging of pN intercellular force and energetic costs during collective cell migration in epithelial wound healing

XH Wang, F Yang, JB Pan, B Kang, JJ Xu… - Analytical …, 2020 - ACS Publications
Collective cell migration plays a key role in tissue repair, metastasis, and development.
Cellular tension is a vital mechanical regulator during the force-driven cell movements …

A hybrid model of intercellular tension and cell–matrix mechanical interactions in a multicellular geometry

LE Scott, LA Griggs, V Narayanan, DE Conway… - … and modeling in …, 2020 - Springer
Epithelial cells form continuous sheets of cells that exist in tensional homeostasis.
Homeostasis is maintained through cell-to-cell junctions that distribute tension and balance …