Wnt proteins are now recognized as one of the major families of developmentally important
signaling molecules, with mutations in Wnt genes displaying remarkable phenotypes in the …

▪ Abstract Wnt genes encode a large family of secreted, cysteine-rich proteins that play key
roles as intercellular signaling molecules in development. Genetic studies in Drosophila and …

Studies on individual types of gynecological cancers (GCs), utilizing novel expression
technologies, have revealed specific pathogenetic patterns and gene markers for cervical …

Wnts are lipid-modified morphogens that play critical roles in development principally
through engagement of Frizzled receptors. The 3.25 angstrom structure of Xenopus Wnt8 …

INTRODUCTION Wnt signaling is an ancient signaling pathway that has accompanied the
emergence of metazoans and is key to many developmental, physiological, and disease …

We have identified three members of a mouse gene family related to the Drosophila
segment polarity gene, hedgehog (h/t). Like h/t, they encode putative secreted proteins and …

The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity,
the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which …

THE amiloride-sensitive epithelial sodium channel constitutes the rate-limiting step for
sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal …

Wnt genes and components of Wnt signalling pathways have been implicated in a wide
spectrum of important biological phenomena, ranging from early organismal development to …

The basal cell nevus syndrome (BCNS) is characterized by developmental abnormalities
and by the postnatal occurrence of cancers, especially basal cell carcinomas (BCCs), the …