Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a
critical role in numerous human physiological and pathological conditions. Thus …

The endocannabinoid system has attracted attention as a pharmacological target for several
pathological conditions. Cannabinoid (CB2)-selective agonists have been the focus of …

The endocannabinoid system, which includes cannabinoid receptor 1 and 2 subtypes
(CB1R and CB2R, respectively), is responsible for the onset of various pathologies including …

Colorectal cancer is the third leading cause of cancer incidence and mortality in the United
States. Cannabidiol (CBD), the second most abundant phytocannabinoid in Cannabis …

Oleanolic acid (OA), a ubiquitous pentacyclic oleanane-type triterpene isolated from edible
and medicinal plants, exhibits a wide spectrum of pharmacological activities and …

The endocannabinoid system (ECS) consists of endogenous cannabinoids, their receptors,
and metabolic enzymes that play a critical homeostatic role in modulating polyunsaturated …

Several studies have implicated the feedback activation of signal transducer and activator of
transcription 3 (STAT3) as a new cancer drug‐resistance mechanism and linked it to the …

Drug-induced nephrotoxicity (DIN) is a major cause of kidney damage and is associated
with high mortality and morbidity, which limits the clinical use of certain therapeutic or …

G protein-coupled receptors (GPCRs) have seven transmembrane spanning domains and
comprise the largest superfamily with~ 800 receptors in humans. GPCRs are attractive …

Covering: 2008 to 2018 Over the last decade more than two hundred single natural products
were confirmed as natural allosteric modulators (alloNPs) of proteins. The compounds are …