Targeting cannabinoid receptors: current status and prospects of natural products
D An, S Peigneur, LA Hendrickx, J Tytgat - International journal of …, 2020 - mdpi.com
Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a
critical role in numerous human physiological and pathological conditions. Thus …
critical role in numerous human physiological and pathological conditions. Thus …
Pharmacological properties, therapeutic potential and molecular mechanisms of JWH133, a CB2 receptor-selective agonist
The endocannabinoid system has attracted attention as a pharmacological target for several
pathological conditions. Cannabinoid (CB2)-selective agonists have been the focus of …
pathological conditions. Cannabinoid (CB2)-selective agonists have been the focus of …
CIRCE: Web-Based Platform for the Prediction of Cannabinoid Receptor Ligands Using Explainable Machine Learning
N Gambacorta, F Ciriaco, N Amoroso… - Journal of Chemical …, 2023 - ACS Publications
The endocannabinoid system, which includes cannabinoid receptor 1 and 2 subtypes
(CB1R and CB2R, respectively), is responsible for the onset of various pathologies including …
(CB1R and CB2R, respectively), is responsible for the onset of various pathologies including …
Cannabidiol exerts anti-proliferative activity via a cannabinoid receptor 2-dependent mechanism in human colorectal cancer cells
HS Lee, G Tamia, HJ Song, D Amarakoon… - International …, 2022 - Elsevier
Colorectal cancer is the third leading cause of cancer incidence and mortality in the United
States. Cannabidiol (CBD), the second most abundant phytocannabinoid in Cannabis …
States. Cannabidiol (CBD), the second most abundant phytocannabinoid in Cannabis …
Recent advances in medicinal chemistry of oleanolic acid derivatives
YH Yang, SY Dai, FH Deng, LH Peng, C Li, YH Pei - Phytochemistry, 2022 - Elsevier
Oleanolic acid (OA), a ubiquitous pentacyclic oleanane-type triterpene isolated from edible
and medicinal plants, exhibits a wide spectrum of pharmacological activities and …
and medicinal plants, exhibits a wide spectrum of pharmacological activities and …
Endocannabinoid system and its regulation by polyunsaturated fatty acids and full spectrum hemp oils
S Komarnytsky, T Rathinasabapathy, C Wagner… - International Journal of …, 2021 - mdpi.com
The endocannabinoid system (ECS) consists of endogenous cannabinoids, their receptors,
and metabolic enzymes that play a critical homeostatic role in modulating polyunsaturated …
and metabolic enzymes that play a critical homeostatic role in modulating polyunsaturated …
Alantolactone sensitizes human pancreatic cancer cells to EGFR inhibitors through the inhibition of STAT3 signaling
H Zheng, L Yang, Y Kang, M Chen, S Lin… - Molecular …, 2019 - Wiley Online Library
Several studies have implicated the feedback activation of signal transducer and activator of
transcription 3 (STAT3) as a new cancer drug‐resistance mechanism and linked it to the …
transcription 3 (STAT3) as a new cancer drug‐resistance mechanism and linked it to the …
Protective effects of natural products against drug-induced nephrotoxicity: A review in recent years
C Gao, C Liu, Y Chen, Q Wang, Z Hao - Food and Chemical Toxicology, 2021 - Elsevier
Drug-induced nephrotoxicity (DIN) is a major cause of kidney damage and is associated
with high mortality and morbidity, which limits the clinical use of certain therapeutic or …
with high mortality and morbidity, which limits the clinical use of certain therapeutic or …
Druggable lipid GPCRs: past, present, and prospects
H Mizuno, Y Kihara - Druggable Lipid Signaling Pathways, 2020 - Springer
G protein-coupled receptors (GPCRs) have seven transmembrane spanning domains and
comprise the largest superfamily with~ 800 receptors in humans. GPCRs are attractive …
comprise the largest superfamily with~ 800 receptors in humans. GPCRs are attractive …
Natural allosteric modulators and their biological targets: molecular signatures and mechanisms
Covering: 2008 to 2018 Over the last decade more than two hundred single natural products
were confirmed as natural allosteric modulators (alloNPs) of proteins. The compounds are …
were confirmed as natural allosteric modulators (alloNPs) of proteins. The compounds are …