Role of the gut microbiota in hematologic cancer

P Guevara-Ramírez, S Cadena-Ullauri… - Frontiers in …, 2023 - frontiersin.org
Hematologic neoplasms represent 6.5% of all cancers worldwide. They are characterized by
the uncontrolled growth of hematopoietic and lymphoid cells and a decreased immune …

Dietary and microbiome evidence in multiple myeloma and other plasma cell disorders

UA Shah, R Parikh, F Castro, M Bellone, AM Lesokhin - Leukemia, 2023 - nature.com
Multiple Myeloma (MM) remains an incurable plasma cell neoplasm. Although little is known
about the etiology of MM, several metabolic risk factors such as obesity, diabetes mellitus …

[HTML][HTML] Multiple myeloma: the (r) evolution of current therapy and a glance into the future

KC Anderson - Haematologica, 2020 - ncbi.nlm.nih.gov
Over the past 20 years, the regulatory approval of several novel agents to treat multiple
myeloma (MM) has prolonged median patient survival from 3 to 8-10 years. Increased …

[HTML][HTML] Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma

Y Zhu, X Jian, S Chen, G An, D Jiang, Q Yang, J Zhang… - Cell Metabolism, 2024 - cell.com
The gut microbiome has been found to play a crucial role in the treatment of multiple
myeloma (MM), which is still considered incurable due to drug resistance. In previous …

Alterations of gut microbiome accelerate multiple myeloma progression by increasing the relative abundances of nitrogen-recycling bacteria

X Jian, Y Zhu, J Ouyang, Y Wang, Q Lei, J Xia, Y Guan… - Microbiome, 2020 - Springer
Background Gut microbiome alterations are closely related to human health and linked to a
variety of diseases. Although great efforts have been made to understand the risk factors for …

Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study

N Khan, S Lindner, ALC Gomes… - Blood, The Journal …, 2021 - ashpublications.org
We previously described clinically relevant reductions in fecal microbiota diversity in patients
undergoing allogeneic hematopoietic cell transplantation (allo-HCT). Recipients of high …

Gut microbiota influence in hematological malignancies: from genesis to cure

M Uribe-Herranz, N Klein-González… - International Journal of …, 2021 - mdpi.com
Hematological malignancies, including multiple myeloma, lymphoma, and leukemia, are a
heterogeneous group of neoplasms that affect the blood, bone marrow, and lymph nodes …

Short-chain fatty acid production by gut microbiota predicts treatment response in multiple myeloma

A Rodríguez-García, A Arroyo, R García-Vicente… - Clinical Cancer …, 2024 - AACR
Purpose: The gut microbiota plays important roles in health and disease. We questioned
whether the gut microbiota and related metabolites are altered in monoclonal …

Inflammation and infection in plasma cell disorders: how pathogens shape the fate of patients

J Caro, M Braunstein, L Williams, B Bruno… - Leukemia, 2022 - nature.com
The role of infection and chronic inflammation in plasma cell disorders (PCD) has been well-
described. Despite not being a diagnostic criterion, infection is a common complication of …

Sustained minimal residual disease negativity in multiple myeloma is associated with stool butyrate and healthier plant-based diets

UA Shah, KH Maclachlan, A Derkach, M Salcedo… - Clinical Cancer …, 2022 - AACR
Purpose: Sustained minimal residual disease (MRD) negativity is associated with long-term
survival in multiple myeloma. The gut microbiome is affected by diet, and in turn can …