Molecular aspects of fructose metabolism and metabolic disease
MA Herman, MJ Birnbaum - Cell metabolism, 2021 - cell.com
Excessive sugar consumption is increasingly considered as a contributor to the emerging
epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet …
epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet …
Dietary fructose and fructose-induced pathologies
The consumption of fructose as sugar and high-fructose corn syrup has markedly increased
during the past several decades. This trend coincides with the exponential rise of metabolic …
during the past several decades. This trend coincides with the exponential rise of metabolic …
Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate
Consumption of fructose has risen markedly in recent decades owing to the use of sucrose
and high-fructose corn syrup in beverages and processed foods, and this has contributed to …
and high-fructose corn syrup in beverages and processed foods, and this has contributed to …
The small intestine converts dietary fructose into glucose and organic acids
Excessive consumption of sweets is a risk factor for metabolic syndrome. A major chemical
feature of sweets is fructose. Despite strong ties between fructose and disease, the …
feature of sweets is fructose. Despite strong ties between fructose and disease, the …
Fructose and sugar: A major mediator of non-alcoholic fatty liver disease
T Jensen, MF Abdelmalek, S Sullivan, KJ Nadeau… - Journal of …, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome; its rising prevalence parallels the rise in obesity and diabetes. Historically …
syndrome; its rising prevalence parallels the rise in obesity and diabetes. Historically …
“Sweet death”: fructose as a metabolic toxin that targets the gut-liver axis
MA Febbraio, M Karin - Cell metabolism, 2021 - cell.com
Glucose and fructose are closely related simple sugars, but fructose has been associated
more closely with metabolic disease. Until the 1960s, the major dietary source of fructose …
more closely with metabolic disease. Until the 1960s, the major dietary source of fructose …
Four key steps control glycolytic flux in mammalian cells
Altered glycolysis is a hallmark of diseases including diabetes and cancer. Despite intensive
study of the contributions of individual glycolytic enzymes, systems-level analyses of flux …
study of the contributions of individual glycolytic enzymes, systems-level analyses of flux …
[HTML][HTML] Metabolic drivers of non-alcoholic fatty liver disease
KK Bence, MJ Birnbaum - Molecular metabolism, 2021 - Elsevier
Background The incidence of non-alcoholic fatty liver disease (NAFLD) is rapidly increasing
worldwide parallel to the global obesity epidemic. NAFLD encompasses a range of liver …
worldwide parallel to the global obesity epidemic. NAFLD encompasses a range of liver …
Inhibition of acetyl-CoA carboxylase by phosphorylation or the inhibitor ND-654 suppresses lipogenesis and hepatocellular carcinoma
The incidence of hepatocellular carcinoma (HCC) is rapidly increasing due to the
prevalence of obesity and non-alcoholic fatty liver disease, but the molecular triggers that …
prevalence of obesity and non-alcoholic fatty liver disease, but the molecular triggers that …
High-fructose corn syrup enhances intestinal tumor growth in mice
Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is
associated with obesity and with an increased risk of colorectal cancer. Whether HFCS …
associated with obesity and with an increased risk of colorectal cancer. Whether HFCS …