Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
Biomolecular condensates are membraneless intracellular assemblies that often form via
liquid− liquid phase separation and have the ability to concentrate biopolymers. Research …
liquid− liquid phase separation and have the ability to concentrate biopolymers. Research …
The proteostasis network and its decline in ageing
Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …
[HTML][HTML] Pathways of cellular proteostasis in aging and disease
CL Klaips, GG Jayaraj, FU Hartl - The Journal of cell biology, 2018 - ncbi.nlm.nih.gov
Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …
In vivo aspects of protein folding and quality control
BACKGROUND Proteins are synthesized on ribosomes as linear chains of amino acids and
must fold into unique three-dimensional structures to fulfill their biological functions. Protein …
must fold into unique three-dimensional structures to fulfill their biological functions. Protein …
p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation
WJ Liu, L Ye, WF Huang, LJ Guo, ZG Xu, HL Wu… - Cellular & molecular …, 2016 - Springer
The ubiquitin–proteasome system (UPS) and autophagy are two distinct and interacting
proteolytic systems. They play critical roles in cell survival under normal conditions and …
proteolytic systems. They play critical roles in cell survival under normal conditions and …
Proteasomal and autophagic degradation systems
I Dikic - Annual review of biochemistry, 2017 - annualreviews.org
Autophagy and the ubiquitin–proteasome system are the two major quality control pathways
responsible for cellular homeostasis. As such, they provide protection against age …
responsible for cellular homeostasis. As such, they provide protection against age …
Protein misfolding in neurodegenerative diseases: implications and strategies
P Sweeney, H Park, M Baumann, J Dunlop… - Translational …, 2017 - Springer
A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein
aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse …
aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse …
Functional amyloids
D Otzen, R Riek - Cold Spring Harbor perspectives in …, 2019 - cshperspectives.cshlp.org
When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-
sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are …
sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are …
The amyloid state and its association with protein misfolding diseases
TPJ Knowles, M Vendruscolo… - Nature reviews Molecular …, 2014 - nature.com
The phenomenon of protein aggregation and amyloid formation has become the subject of
rapidly increasing research activities across a wide range of scientific disciplines. Such …
rapidly increasing research activities across a wide range of scientific disciplines. Such …
An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function
Stress granules (SG) are membrane‐less compartments involved in regulating mRNAs
during stress. Aberrant forms of SGs have been implicated in age‐related diseases, such as …
during stress. Aberrant forms of SGs have been implicated in age‐related diseases, such as …