Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …

Immunoglobulin A (IgA) plays a key role in defending mucosal surfaces against attack by
infectious microorganisms. Such sites present a major site of susceptibility due to their vast …

The vast surfaces of the gastrointestinal, respiratory, and genitourinary tracts represent
major sites of potential attack by invading micro‐organisms. Immunoglobulin A (IgA), as the …

Immunoglobulin A (IgA) has a critical role in immune defense particularly at the mucosal
surfaces, and is equipped to do so by the unique structural attributes of its heavy chain and …

Immunoglobulins (Igs) play key roles in immune protection of mucosal surfaces that form an
immense and vulnerable interface with the environment. In humans, the principal Ig in most …

The joining (J) chain is a small polypeptide, expressed by mucosal and glandular plasma
cells, which regulates polymer formation of immunoglobulin (Ig) A and IgM. J‐chain …

Intestinal microfold (M) cells possess a high transcytosis capacity and are able to transport a
broad range of materials including particulate antigens, soluble macromolecules, and …

As central effectors of the adaptive immune response, immunoglobulins, or antibodies,
provide essential protection from pathogens through their ability to recognize foreign …

Local production of secretory (S) IgA provides adaptive immunologic protection of mucosal
surfaces, but SIgA is also protective when administered passively, such as in breast milk …

Background: Extensive efforts have been made in optimizing monoclonal immunoglobulin
(Ig) G antibodies for use in clinical practice. Accumulating evidence suggests that IgA or anti …