Background: Preeclampsia (PE) is a syndromic disorder that affects 2% to 8% of
pregnancies and is diagnosed principally when hypertension appears in the second-d half …

Abstract This Brief Review delves into B cell responses in the context of allergy. The primary
contribution of B cells to allergy is the production of IgE, the Ab isotype that triggers …

IgE antibodies may elicit potent allergic reactions, and their production is tightly controlled.
The tendency to generate IgE has been thought to reflect the balance between type 1 and …

Objectives: Luteolin is the active component of Perilla frutescens, an herb for the treatment of
allergy in Asia. In this study, we aimed to investigate the effects and mechanisms of luteolin …

Immunoglobulin E (IgE) responses are a central feature of allergic disease. Using a well-
established food-allergy model in mice, we show that two sensitizations with cognate B cell …

The proper regulation of IgE production safeguards against allergic disease, highlighting the
importance of mechanisms that restrict IgE plasma cell (PC) survival. IgE PCs have …

It is unknown whether the incremental increases in BCL6 amounts in antigen-activated B
cells influence the unfolding differentiation before germinal center (GC) formation. By …

AB cell culture system using BAFF, IL‐4 and IL‐21 was recently developed that generates B
cells with phenotypic and functional characteristics of in vivo‐generated germinal center …

Allergic diseases consist of improper inflammatory reactions to antigens and are currently an
important healthcare concern, especially considering their increasing worldwide …

Background IgE production against innocuous food antigens can result in anaphylaxis, a
severe life-threatening consequence of allergic reactions. The maintenance of IgE immunity …