Fabrication of smart tantalum carbide MXene quantum dots with intrinsic immunomodulatory properties for treatment of allograft vasculopathy

A Rafieerad, W Yan, KN Alagarsamy… - Advanced Functional …, 2021 - Wiley Online Library
MXene nanomaterials have sparked significant interest among interdisciplinary researchers
to tackle today's medical challenges. In particular, colloidal MXene quantum dots (MQDs) …

[HTML][HTML] Immunoengineered MXene nanosystem for mitigation of alloantigen presentation and prevention of transplant vasculopathy

W Yan, A Rafieerad, KN Alagarsamy, LR Saleth… - Nano Today, 2023 - Elsevier
MXenes are an emerging class of nanomaterials with significant potential for applications in
nanomedicine. Amongst MXene technologies, titanium carbide (Ti 3 C 2 T x) nanomaterials …

Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7

A Vergani, S Tezza, F D'Addio, C Fotino, K Liu… - Circulation, 2013 - Am Heart Assoc
Background—Heart transplantation is a lifesaving procedure for patients with end-stage
heart failure. Despite much effort and advances in the field, current immunosuppressive …

Pediatric coronary allograft vasculopathy—a review of pathogenesis and risk factors

KR Schumacher, RJ Gajarski… - Congenital Heart …, 2012 - Wiley Online Library
Coronary allograft vasculopathy is the current leading cause for late graft loss following
cardiac transplantation. Its pathogenesis is multifactorial, including immune, constitutional …

Disruption of the gut microbiota with antibiotics exacerbates acute vascular rejection

K Rey, S Manku, W Enns, T Van Rossum… - …, 2018 - journals.lww.com
Background The gut microbiota influences many immunological processes but how its
disruption affects transplant rejection is poorly understood. Methods Interposition grafting of …

Natural killer cells play a critical role in cardiac allograft vasculopathy in an interleukin-6–dependent manner

ZX Zhang, X Huang, J Jiang, D Lian, W Min… - …, 2014 - journals.lww.com
Background Approximately 50% of cardiac transplants fail in the long term, and currently,
there are no specific treatments to prevent chronic rejection. In the clinic, donor cardiac graft …

Cytomegalovirus chemokine receptor M33 knockout reduces chronic allograft rejection in a murine aortic transplant model

NM Fritz, T Stamminger, M Ramsperger-Gleixner… - Transplant …, 2021 - Elsevier
Background Numerous studies suggest that cytomegalovirus (CMV) infection may act as
isolated risk factor in the development of cardiac allograft vasculopathy (CAV). Viral G …

MicroRNA-155 promotes the directional migration of resident smooth muscle progenitor cells by regulating monocyte chemoattractant protein 1 in transplant …

Y Sun, K Wang, P Ye, J Wu, L Ren… - … , and vascular biology, 2016 - Am Heart Assoc
Objective—Smooth muscle–like cells are major cell components of transplant
arteriosclerosis lesions. This study investigated the origin of the smooth muscle–like cells …

Early innate immune events induced by prolonged cold ischemia exacerbate allograft vasculopathy

JJ Devitt, CL King, TDG Lee… - Journal of cardiothoracic …, 2011 - Springer
Background Ischemia/reperfusion induced innate immune injury is inescapable in solid
organ transplantation. Prolonged cold ischemia exacerbates the primary manifestation of …

First case of donor transmitted non-leukemic promyelocytic sarcoma

T Williams, OS Aljitawi, R Moussa, S McHugh… - Leukemia & …, 2012 - Taylor & Francis
Malignancy after solid organ or stem cell transplant can occur in three distinct ways: de
novo, recurrent in the recipient, or transmission from donor to recipient [1]. According to an …