LPA receptor signaling: pharmacology, physiology, and pathophysiology
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
Lysophospholipid receptor nomenclature review: IUPHAR Review 8
Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids
that act as extracellular signals. The signalling properties are mediated by 7 …
that act as extracellular signals. The signalling properties are mediated by 7 …
The druggability of solute carriers
The transport of materials across membranes is a vital process for all aspects of cellular
function, including growth, metabolism, and communication. Protein transporters are the …
function, including growth, metabolism, and communication. Protein transporters are the …
Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome
Background DNA methylation is an epigenetic mechanism central to development and
maintenance of complex mammalian tissues, but our understanding of its role in intestinal …
maintenance of complex mammalian tissues, but our understanding of its role in intestinal …
[HTML][HTML] The Role of Ion Transporters in the Pathophysiology of InfectiousáDiarrhea
S Das, R Jayaratne, KE Barrett - Cellular and molecular gastroenterology …, 2018 - Elsevier
Every year, enteric infections and associated diarrhea kill millions of people. The situation is
compounded by increases in the number of enteric pathogens that are acquiring resistance …
compounded by increases in the number of enteric pathogens that are acquiring resistance …
Lysophosphatidic acid, a simple phospholipid with myriad functions
K Yanagida, T Shimizu - Pharmacology & Therapeutics, 2023 - Elsevier
Lysophosphatidic acid (LPA) is a simple phospholipid consisting of a phosphate group,
glycerol moiety, and only one hydrocarbon chain. Despite its simple chemical structure, LPA …
glycerol moiety, and only one hydrocarbon chain. Despite its simple chemical structure, LPA …
Development of a unique small molecule modulator of CXCR4
Z Liang, W Zhan, A Zhu, Y Yoon, S Lin, M Sasaki… - PloS one, 2012 - journals.plos.org
Background Metastasis, the spread and growth of tumor cells to distant organ sites,
represents the most devastating attribute and plays a major role in the morbidity and …
represents the most devastating attribute and plays a major role in the morbidity and …
Lysophosphatidic acid (LPA) receptor modulators: Structural features and recent development
Lysophosphatidic acid (LPA) activates six LPA receptors (LPAR 1-6) and regulates various
cellular activities such as cell proliferation, cytoprotection, and wound healing. Many studies …
cellular activities such as cell proliferation, cytoprotection, and wound healing. Many studies …
[HTML][HTML] Lysophosphatidic acid receptors: biochemical and clinical implications in different diseases
H Xiang, Y Lu, M Shao, T Wu - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
Abstract Lysophosphatidic acid (LPA, 1-acyl-2-hemolytic-sn-glycerol-3-phosphate) extracted
from membrane phospholipid is a kind of simple bioactive glycophospholipid, which has …
from membrane phospholipid is a kind of simple bioactive glycophospholipid, which has …
Regulation of G protein-coupled receptor function by Na+/H+ exchange regulatory factors
Many G protein-coupled receptors (GPCR) exert patterns of cell-specific signaling and
function. Mounting evidence now supports the view that cytoplasmic adapter proteins …
function. Mounting evidence now supports the view that cytoplasmic adapter proteins …