Cytoplasmic steps of peptidoglycan biosynthesis
H Barreteau, A Kovač, A Boniface… - FEMS microbiology …, 2008 - academic.oup.com
The biosynthesis of bacterial cell wall peptidoglycan is a complex process that involves
enzyme reactions that take place in the cytoplasm (synthesis of the nucleotide precursors) …
enzyme reactions that take place in the cytoplasm (synthesis of the nucleotide precursors) …
Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development
GL Moraes, GC Gomes, PRM De Sousa, CN Alves… - Tuberculosis, 2015 - Elsevier
Tuberculosis (TB) is the second leading cause of human mortality from infectious diseases
worldwide. The WHO reported 1.3 million deaths and 8.6 million new cases of TB in 2012 …
worldwide. The WHO reported 1.3 million deaths and 8.6 million new cases of TB in 2012 …
Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release
S Eschenburg, M Priestman, E Schönbrunn - Journal of Biological …, 2005 - ASBMB
MurA (UDP-N-acetylglucosamine enolpyruvyl transferase, EC 2.5. 1.7) is an essential
enzyme in the biosynthesis of the peptidoglycan layer of the bacterial cell. It provides an …
enzyme in the biosynthesis of the peptidoglycan layer of the bacterial cell. It provides an …
A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA)
S Eschenburg, MA Priestman, FA Abdul-Latif… - Journal of Biological …, 2005 - ASBMB
MurA (UDP-N-acetylglucosamine enolpyruvyl transferase, EC 2.5. 1.7) catalyzes the first
committed step in the synthesis of the bacterial cell wall. It is the target of the naturally …
committed step in the synthesis of the bacterial cell wall. It is the target of the naturally …
UDP-N-acetylmuramic Acid (UDP-MurNAc) Is a Potent Inhibitor of MurA (Enolpyruvyl-UDP-GlcNAc Synthase)
S Mizyed, A Oddone, B Byczynski, DW Hughes… - Biochemistry, 2005 - ACS Publications
Purified recombinant MurA (enolpyruvyl-UDP-GlcNAc synthase) overexpressed in
Escherichia coli had significant amounts of UDP-MurNAc (UDP-N-acetylmuramic acid) …
Escherichia coli had significant amounts of UDP-MurNAc (UDP-N-acetylmuramic acid) …
[PDF][PDF] The shikimate pathway in apicomplexan parasites: implications for drug development
B Derrer, P Macheroux, B Kappes - Front Biosci (Landmark Ed), 2013 - researchgate.net
Introduction–reactions of the shikimate pathway 3. Biochemical characteristics of shikimate
pathway enzymes 3.1. 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAHPS) …
pathway enzymes 3.1. 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAHPS) …
[HTML][HTML] Transcriptome analysis reveals differences in developmental neurotoxicity mechanism of methyl-, ethyl-, and propyl-parabens in zebrafish embryos
Studies on the comparison of developmental (neuro) toxicity of parabens are currently
limited, and unharmonized concentrations between phenotypic observations and …
limited, and unharmonized concentrations between phenotypic observations and …
Lyme Disease Enolpyruvyl-UDP-GlcNAc Synthase: Fosfomycin-Resistant MurA from Borrelia burgdorferi, a Fosfomycin-Sensitive Mutant, and the Catalytic Role of the …
S Jiang, ME Gilpin, M Attia, YL Ting, PJ Berti - Biochemistry, 2011 - ACS Publications
MurAs (enolpyruvyl-UDP-GlcNAc synthases) from pathogenic bacteria such as Borrelia
burgdorferi (Lyme disease) and tuberculosis are fosfomycin resistant because an Asp-for …
burgdorferi (Lyme disease) and tuberculosis are fosfomycin resistant because an Asp-for …
Implications of Protonation and Substituent Effects for C− O and O− P Bond Cleavage in Phosphate Monoesters
PG Loncke, PJ Berti - Journal of the American Chemical Society, 2006 - ACS Publications
A recent study of phosphate monoesters that broke down exclusively through C− O bond
cleavage and whose reactivity was unaffected by protonation of the nonbridging oxygens …
cleavage and whose reactivity was unaffected by protonation of the nonbridging oxygens …
Linear Free Energy Relationship Analysis of Transition State Mimicry by 3-Deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) Oxime, a DAHP Synthase Inhibitor …
N Balachandran, F To, PJ Berti - Biochemistry, 2017 - ACS Publications
3-Deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) synthase catalyzes an aldol-like
reaction of phosphoenolpyruvate (PEP) with erythrose 4-phosphate (E4P) to form DAHP in …
reaction of phosphoenolpyruvate (PEP) with erythrose 4-phosphate (E4P) to form DAHP in …