The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity
ERK MAP kinase signaling plays a pivotal role in diverse cellular functions, including cell
proliferation, differentiation, migration and survival. One of the central questions concerning …
proliferation, differentiation, migration and survival. One of the central questions concerning …
Signal integration during development: Insights from the Drosophila eye
MG Voas, I Rebay - … dynamics: an official publication of the …, 2004 - Wiley Online Library
The Drosophila eye is a highly ordered epithelial tissue composed of∼ 750 subunits called
ommatidia arranged in a reiterated hexagonal pattern. At higher resolution, observation of …
ommatidia arranged in a reiterated hexagonal pattern. At higher resolution, observation of …
[HTML][HTML] Competition for space induces cell elimination through compaction-driven ERK downregulation
The plasticity of developing tissues relies on the adjustment of cell survival and growth rate
to environmental cues. This includes the effect of mechanical cues on cell survival …
to environmental cues. This includes the effect of mechanical cues on cell survival …
The nuclear translocation of mitogen-activated protein kinases: molecular mechanisms and use as novel therapeutic target
The mitogen-activated protein kinase (MAPK) cascades are central signaling pathways that
play a central role in the regulation of most stimulated cellular processes including …
play a central role in the regulation of most stimulated cellular processes including …
Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk
DB Doroquez, I Rebay - Critical reviews in biochemistry and …, 2006 - Taylor & Francis
Metazoan development relies on a highly regulated network of interactions between
conserved signal transduction pathways to coordinate all aspects of cell fate specification …
conserved signal transduction pathways to coordinate all aspects of cell fate specification …
[HTML][HTML] A muscle-specific p38 MAPK/Mef2/MnSOD pathway regulates stress, motor function, and life span in Drosophila
Molecular mechanisms that concordantly regulate stress, life span, and aging remain
incompletely understood. Here, we demonstrate that in Drosophila, a p38 MAP kinase …
incompletely understood. Here, we demonstrate that in Drosophila, a p38 MAP kinase …
Control of MAP kinase signaling to the nucleus
MAP kinase (MAPK) signaling is among central signaling pathways that regulate cell
proliferation, cell differentiation and apoptosis. As MAPK should transmit extracellular …
proliferation, cell differentiation and apoptosis. As MAPK should transmit extracellular …
Inhibition of ERK‐MAP kinase signaling by RSK during Drosophila development
Although p90 ribosomal S6 kinase (RSK) is known as an important downstream effector of
the ribosomal protein S6 kinase/extracellular signal‐regulated kinase (Ras/ERK) pathway …
the ribosomal protein S6 kinase/extracellular signal‐regulated kinase (Ras/ERK) pathway …
The proneural proteins Atonal and Scute regulate neural target genes through different E-box binding sites
LM Powell, PI Zur Lage, DRA Prentice… - … and cellular biology, 2004 - Taylor & Francis
For a particular functional family of basic helix-loop-helix (bHLH) transcription factors, there
is ample evidence that different factors regulate different target genes but little idea of how …
is ample evidence that different factors regulate different target genes but little idea of how …
[HTML][HTML] Fragile X protein functions with lgl and the par complex in flies and mice
Fragile X syndrome, the most common form of inherited mental retardation, is caused by loss
of function for the Fragile X Mental Retardation 1 gene (FMR1). FMR1 protein (FMRP) has …
of function for the Fragile X Mental Retardation 1 gene (FMR1). FMR1 protein (FMRP) has …