Advances in organ-on-a-chip engineering
Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …
and discovery processes. The cost of drug discovery is steadily increasing owing to the …
Microfluidics for drug development: from synthesis to evaluation
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …
delivery, and drug evaluation. Compared with conventional drug development procedures …
Bioinspired living structural color hydrogels
Structural color materials from existing natural organisms have been widely studied to
enable artificial manufacture. Variable iridescence has attracted particular interest because …
enable artificial manufacture. Variable iridescence has attracted particular interest because …
Organ‐on‐chip models: implications in drug discovery and clinical applications
R Mittal, FW Woo, CS Castro, MA Cohen… - Journal of cellular …, 2019 - Wiley Online Library
Before a lead compound goes through a clinical trial, preclinical studies utilize two‐
dimensional (2D) in vitro models and animal models to study the pharmacodynamics and …
dimensional (2D) in vitro models and animal models to study the pharmacodynamics and …
3D bioprinting for cardiovascular regeneration and pharmacology
Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide.
Compared to traditional therapeutic strategies, three-dimensional (3D) bioprinting is one of …
Compared to traditional therapeutic strategies, three-dimensional (3D) bioprinting is one of …
Microfluidic trends in drug screening and drug delivery
The low probability of a drug candidate's clinical success, the time consumed and the high
cost of bringing a drug from concept to market emphasizes the need for new approaches to …
cost of bringing a drug from concept to market emphasizes the need for new approaches to …
Cardiac tissues from stem cells: new routes to maturation and cardiac regeneration
G Campostrini, LM Windt, BJ van Meer… - Circulation …, 2021 - Am Heart Assoc
The ability of human pluripotent stem cells to form all cells of the body has provided many
opportunities to study disease and produce cells that can be used for therapy in …
opportunities to study disease and produce cells that can be used for therapy in …
Microengineered platforms for characterizing the contractile function of in vitro cardiac models
Emerging heart-on-a-chip platforms are promising approaches to establish cardiac
cell/tissue models in vitro for research on cardiac physiology, disease modeling and drug …
cell/tissue models in vitro for research on cardiac physiology, disease modeling and drug …
I-Wire Heart-on-a-Chip I: Three-dimensional cardiac tissue constructs for physiology and pharmacology
VY Sidorov, PC Samson, TN Sidorova, JM Davidson… - Acta biomaterialia, 2017 - Elsevier
Engineered 3D cardiac tissue constructs (ECTCs) can replicate complex cardiac physiology
under normal and pathological conditions. Currently, most measurements of ECTC …
under normal and pathological conditions. Currently, most measurements of ECTC …