Recent Advances in Nanomechanical Measurements and Their Application for Pharmaceutical Crystals

MK Mishra, P Mahur, P Manimunda… - Molecular …, 2023 - ACS Publications
Mechanical behavior of pharmaceutical crystals directly impacts the formulation
development and manufacturing of drug products. The understanding of crystal structure …

Nanomechanical testing in drug delivery: Theory, applications, and emerging trends

S Majumder, CC Sun, NA Mara - Advanced Drug Delivery Reviews, 2022 - Elsevier
Mechanical properties play a central role in drug formulation development and
manufacturing. Traditional characterization of mechanical properties of pharmaceutical …

Elastic molecular crystals: From serendipity to design to applications

S Ghosh, MK Mishra - Crystal Growth & Design, 2021 - ACS Publications
The mechanical adaptiveness of long-range ordered molecular crystals has long been
ignored due to their brittle nature, unlike polymers and flexible biomaterials. However, the …

Structural basis for mechanical anisotropy in polymorphs of a caffeine–glutaric acid cocrystal

MK Mishra, K Mishra, A Narayan, CM Reddy… - Crystal Growth & …, 2020 - ACS Publications
Insights into structure–mechanical property correlations in molecular and multicomponent
crystals have recently attracted significant attention owing to their practical applications in …

Structural analysis of elastically bent organic crystals using in situ indentation and micro-Raman spectroscopy

MK Mishra, K Mishra, SAS Asif… - Chemical …, 2017 - pubs.rsc.org
The structural dynamics of two elastically bendable, halogenated N-benzylideneaniline
organic crystals were studied using an in situ three-point bending test and Raman …

Indentation plasticity and fracture studies of organic crystals

S Mannepalli, KSRN Mangalampalli - Crystals, 2017 - mdpi.com
This review article summarizes the recent advances in measuring and understanding the
indentation-induced plastic deformation and fracture behavior of single crystals of a wide …

Probing stress induced phase transformation in aspirin polymorphs using Raman spectroscopy enabled nanoindentation

P Manimunda, SAS Asif, MK Mishra - Chemical Communications, 2019 - pubs.rsc.org
Nanoindentation has extensively been used to measure the mechanical properties of
molecular crystals. However, the possibilities of stress induced polymorphic transformation …

A review on micro-and nanoscratching/tribology at high temperatures: instrumentation and experimentation

SZ Chavoshi, S Xu - Journal of Materials Engineering and Performance, 2018 - Springer
High-temperature micro-/nanomechanics has attracted much interest over the last decade,
primarily because of the urgent need to understand the mechanical and tribological …

High Ratio of Hardness and Elastic Modulus (H/E) Studied by the Nanoindentation Technique of Acetaminophen with Corrugated Slip Planes

F Wei, W Zhang, C Zhang, Y Tian, S Wu… - Crystal Growth & …, 2022 - ACS Publications
Acetaminophen is a widely used analgesic and antipyretic drug. The mechanical properties
of drugs are vital for tableting and bioavailability. This paper studied the mechanical …

Molecular basis for the mechanical response of sulfa drug crystals

S SeethaLekshmi, MSRN Kiran… - … A European Journal, 2019 - Wiley Online Library
Comprehension of the nanomechanical response of crystalline materials requires the
understanding of the elastic and plastic deformation mechanisms in terms of the underlying …