Importance of P-gp inhibitors and nanoengineered approaches for effective delivery of anti-retroviral drugs across barriers in HIV management
HIV infection has been a major global public health issue that hinders the body's ability to
fight against the disease. For their treatment, antiretroviral therapy (ART) has been used to …
fight against the disease. For their treatment, antiretroviral therapy (ART) has been used to …
Pharmacological effects and mechanisms of paeonol on antitumor and prevention of side effects of cancer therapy
X Chang, X Feng, M Du, S Li, J Wang… - Frontiers in …, 2023 - frontiersin.org
Cancer represents one of the leading causes of mortality worldwide. Conventional clinical
treatments include radiation therapy, chemotherapy, immunotherapy, and targeted therapy …
treatments include radiation therapy, chemotherapy, immunotherapy, and targeted therapy …
Mechanisms of Antidiabetic Activity of Methanolic Extract of Punica granatum Leaves in Nicotinamide/Streptozotocin-Induced Type 2 Diabetes in Rats
The current study aimed to establish the mechanisms of antidiabetic activity of methanolic
extract of Punica granatum leaves (MEPGL) in nicotinamide/streptozotocin-induced type 2 …
extract of Punica granatum leaves (MEPGL) in nicotinamide/streptozotocin-induced type 2 …
Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis
ZL Jin, WY Gao, SJ Liao, T Yu, Q Shi, SZ Yu… - ASN neuro, 2021 - journals.sagepub.com
Intracerebral haemorrhage (ICH) is a devastating subtype of stroke with high morbidity and
mortality. It has been reported that paeonol (PAN) inhibits the progression of ICH. However …
mortality. It has been reported that paeonol (PAN) inhibits the progression of ICH. However …
Paeonol Protects Against Methotrexate-Induced Nephrotoxicity via Upregulation of P-gp Expression and Inhibition of TLR4/NF-κB Pathway
Methotrexate (MTX) is a well-known anticancer drug that causes nephrotoxicity as a side
effect. To investigate the mechanisms by which paeonol, a natural phenolic compound, can …
effect. To investigate the mechanisms by which paeonol, a natural phenolic compound, can …
[HTML][HTML] Ginkgo biloba extract (EGb 761) mitigates methotrexate-induced testicular insult in rats: Targeting oxidative stress, energy deficit and spermatogenesis
DF Mansour, DO Saleh, OA Ahmed-Farid… - Biomedicine & …, 2021 - Elsevier
Methotrexate (MTX) is commonly used as a therapeutic agent in the treatment of
malignancies and autoimmune disorders. Risk of subsequent infertility following MTX …
malignancies and autoimmune disorders. Risk of subsequent infertility following MTX …
[HTML][HTML] Paeonol repurposing for cancer therapy: From mechanism to clinical translation
Y Wang, BS Li, ZH Zhang, Z Wang, YT Wan… - Biomedicine & …, 2023 - Elsevier
Paeonol (PAE) is a natural phenolic monomer isolated from the root bark of Paeonia
suffruticosa that has been widely used in the clinical treatment of some inflammatory-related …
suffruticosa that has been widely used in the clinical treatment of some inflammatory-related …
The impact of Nrf2/HO-1, caspase-3/Bax/Bcl2 and ATF6/IRE1/PERK/GRP78 signaling pathways in the ameliorative effects of morin against methotrexate-induced …
Background Methotrexate (MT) is a broadly used chemotherapeutic drug however its clinical
use is confronted with several forms of toxicities containing testicular damage. The current …
use is confronted with several forms of toxicities containing testicular damage. The current …
A comparative study of particulate matter between New Delhi, India and Riyadh, Saudi Arabia during the COVID-19 lockdown period
BP Singh, GE Eldesoky, P Kumar… - Frontiers in …, 2022 - frontiersin.org
Novel Coronavirus disease (COVID-19), after being identified in late December 2019 in
Wuhan city of China, spread very fast and has affected all the countries in the world. The …
Wuhan city of China, spread very fast and has affected all the countries in the world. The …
Paeonol Protects against Methotrexate Hepatotoxicity by Repressing Oxidative Stress, Inflammation, and Apoptosis—The Role of Drug Efflux Transporters
Methotrexate (MTX) is an effective chemotherapeutic agent against a wide range of tumors
and autoimmune diseases; however, hepatotoxicity limits its clinical use. Oxidative stress …
and autoimmune diseases; however, hepatotoxicity limits its clinical use. Oxidative stress …