Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …

Estrogen receptor β (ERβ) is closely related to breast cancer (BC) progression. Traditional
concepts regard ERβ as a tumor suppressor. As studies show the carcinogenic effect of …

A great hallmark of breast cancer is the absence or presence of estrogen receptors ERα and
ERβ, with a dominant role in cell proliferation, differentiation and cancer progression. Both …

Synthesis, deposition, and interactions of hyaluronan (HA) with its cellular receptor CD44
are crucial events that regulate the onset and progression of tumors. The intracellular …

Background Estrogen receptor β (ERβ) has been reported to play an anti-cancer role in
breast cancer, but the regulatory mechanism by which ERβ exerts this effect is not clear …

Alzheimer's disease (AD) is the most common form of dementia, characterized by
accumulation of amyloid β (Aβ) and neurofibrillary tangles. Oxidative stress and …

Estradiol (E2) is a major hormone controlling women fertility, in particular folliculogenesis.
This steroid, which is locally produced by granulosa cells (GC) within ovarian follicles …

Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …

Despite considering vast majority of the transcribed molecules as merely noise RNA in the
last decades, recent advances in the field of molecular biology revealed the mysterious role …