The secretory pathway is responsible for the synthesis, folding, and delivery of a diverse
array of cellular proteins. Secretory protein synthesis begins in the endoplasmic reticulum …

Membrane proteins are inserted into the endoplasmic reticulum (ER) by two highly
conserved parallel pathways. The well-studied co-translational pathway uses signal …

Integral membrane proteins of the cell surface and most intracellular compartments of
eukaryotic cells are assembled at the endoplasmic reticulum. Two highly conserved and …

Hundreds of proteins are inserted post-translationally into the endoplasmic reticulum (ER)
membrane by a single carboxy-terminal transmembrane domain (TMD). During targeting …

A large group of diverse, functionally important, and differently localized transmembrane
proteins, share a particular membrane topology, consisting of a cytosolic N-terminal region …

Tail-anchored (TA) proteins are posttranslationally inserted into either the endoplasmic
reticulum (ER) or the mitochondrial outer membrane. The C-terminal transmembrane …

Tail-anchored (TA) membrane proteins destined for the endoplasmic reticulum are
chaperoned by cytosolic targeting factors that deliver them to a membrane receptor for …

Proper localization of membrane proteins is essential for the function of biological
membranes and for the establishment of organelle identity within a cell. Molecular …

Membrane protein biogenesis poses acute challenges to protein homeostasis, and how they
are selectively escorted to the target membrane is not well understood. Here we address this …

Tail-anchored (TA) proteins fulfill diverse cellular functions within different organellar
membranes. Their characteristic C-terminal transmembrane segment renders TA proteins …