The growing body of evidence recognizing the adipose tissue (AT) as an active endocrine
organ secreting bioactive mediators involved in metabolic and inflammatory disorders …

Pathway analysis is often the first choice for studying the mechanisms underlying a
phenotype. However, conventional methods for pathway analysis do not take into account …

Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects the joints.
Organokines can produce beneficial or harmful effects in this condition. Among RA patients …

Background Angiogenesis plays an important role in the development of rheumatoid arthritis
(RA), which increases the supply of nutrients, cytokines, and inflammatory cells to the …

Objectives The aim of this paper was to analyse the impact of obesity, in addition to known
predictors, on disease outcome in early rheumatoid arthritis (RA). Methods Body mass index …

Rheumatoid arthritis affects millions of people worldwide and is considered a chronic
multisystem disease whose causes are unknown. In general, the main objective of …

Background Chemerin has a potential role in perpetuating inflammation in autoimmune
diseases. Nevertheless, to date, there is no conclusive information on whether high …

Over the past few decades, our understanding of the role of adipose tissue has changed
dramatically. Far from simply being a site of energy storage or a modulator of the endocrine …

Patients with rheumatoid arthritis (RA) are at increased risk of cardiovascular disease.
Dyslipidemia is a known adverse effect of tocilizumab (TCZ), an anti-interleukin-6 receptor …

The frequent coexistence of obesity and metabolic syndrome in patients with alopecia
areata may indicate the common pathogenetic pathway in these conditions with an …