This review discusses a set of instrumental and computational methods that are used to
characterize hydrated forms of APIs (active pharmaceutical ingredients). The focus has been …

Since the discovery of X-ray diffraction and its potential to elucidate crystal symmetry,
powder X-ray diffraction has found diverse applications in the field of pharmaceutical …

Cocrystals are long known yet recently applied molecular entities. In the past decade, a
significant potential has been demonstrated by these novel solids in terms of modifying the …

Recent active research and new regulatory guidance on pharmaceutical cocrystals have
increased the rate of their development as promising approaches to improve handling …

This article reports on the preparation and solid-state characterization of an indomethacin–
caffeine drug–drug cocrystal (or codrug) in a 1: 1 stoichiometry. These two active ingredients …

Phase transformation of an active pharmaceutical ingredient in the solid state can influence
the physicochemical properties and consequently drug product performance. The neat …

The stability of different theophylline cocrystals under milling conditions was investigated by
competitive cocrystal reactions. To determine the most stable cocrystal form under milling …

Caffeine–oxalic acid cocrystal, widely reported to be stable under high humidity, dissociated
in the presence of numerous pharmaceutical excipients. In cocrystal–excipient binary …

We report the first multicomponent crystal of desloratadine, an important anti-histamine drug,
with a pharmaceutically acceptable coformer of benzoic acid. The single crystal structure …

The thermal behavior, phase stability, indicative stability and intrinsic dissolution rates of a
series of cocrystals and cocrystal hydrates derived from the pharmaceutically active …