The mechanisms regulating the development and function of the immune system are diverse
and complicated. The signaling pathways and target genes that become activated upon cell …

The past two years have seen significant advances in our understanding of IL-2 gene
transcription. Many of the relevant transcription factors have been identified, the intracellular …

Over the past 15 years, a wealth of information has been published on transcripts and
proteins 'induced'(requiring new protein synthesis) in mammalian cells after ionizing …

A consensus cyclic AMP response element (CRE) in the murine prostaglandin synthase-2
(PGS2) promoter is essential for pgs2 gene expression induced by pp60 v-src, the v-src …

Protein Kinase C (PKC) is a family of serine–threonine kinases found in most cell types
whose activity has a strong influence on a wide variety of signal transduction events …

UVA exposure plays an important role in the etiology of skin cancer. The family of p90-kDa
ribosomal S6 kinases (p90 RSK/MAPKAP-K1) are activated via phosphorylation. In this …

B and T lymphocytes of the immune system recognize and destroy invading microorganisms
but are tolerant to the cells and tissues of one's own body. The basis for this selflnon-self …

Since its introduction to clinical medicine in 1978, the fungal metabolite cyclosporin A (CyA)
has developed into the standard drug for preventing rejection of organ transplants. It also …

Protein-tyrosine phosphatase (PTP) inhibitors are potent activators of T lymphocytes, most
likely by affecting the early steps of T cell receptor (TCR) signaling. We have analyzed the …

The JB6 cell culture model is used to identify molecular determinants of susceptibility to the
promotion of neoplastic transformation. Clonal variants susceptible to transformation …