Reinventing the human tuberculosis (TB) granuloma: Learning from the cancer field
S Ashenafi, S Brighenti - Frontiers in Immunology, 2022 - frontiersin.org
Tuberculosis (TB) remains one of the deadliest infectious diseases in the world and every 20
seconds a person dies from TB. An important attribute of human TB is induction of a …
seconds a person dies from TB. An important attribute of human TB is induction of a …
Role of immune cells and receptors in cancer treatment: an immunotherapeutic approach
AG Mukherjee, UR Wanjari, A Namachivayam… - Vaccines, 2022 - mdpi.com
Cancer immunotherapy moderates the immune system's ability to fight cancer. Due to its
extreme complexity, scientists are working to put together all the puzzle pieces to get a …
extreme complexity, scientists are working to put together all the puzzle pieces to get a …
Autophagy promotes efficient T cell responses to restrict high-dose Mycobacterium tuberculosis infection in mice
S Feng, ME McNehlan, RL Kinsella… - Nature …, 2024 - nature.com
Although autophagy sequesters Mycobacterium tuberculosis (Mtb) in in vitro cultured
macrophages, loss of autophagy in macrophages in vivo does not result in susceptibility to a …
macrophages, loss of autophagy in macrophages in vivo does not result in susceptibility to a …
Inflammatory immune profiles associated with disease severity in pulmonary tuberculosis patients with moderate to severe clinical TB or anemia
S Ashenafi, MG Loreti, A Bekele, G Aseffa… - Frontiers in …, 2023 - frontiersin.org
Background Immune control of Mycobacterium tuberculosis (Mtb) infection is largely
influenced by the extensive disease heterogeneity that is typical for tuberculosis (TB). In this …
influenced by the extensive disease heterogeneity that is typical for tuberculosis (TB). In this …
Suppressive myeloid cells in SARS-CoV-2 and Mycobacterium tuberculosis co-infection
Epidemiologic data show that both current and previous tuberculosis (TB) increase the risk
of in-hospital mortality from coronavirus disease-2019 (COVID-19), and there is a similar …
of in-hospital mortality from coronavirus disease-2019 (COVID-19), and there is a similar …
[HTML][HTML] Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapy
Abstract The expression of indoleamine 2, 3-dioxygenase (IDO), a robust
immunosuppressant, is significantly induced in macaque tuberculosis (TB) granulomas …
immunosuppressant, is significantly induced in macaque tuberculosis (TB) granulomas …
Immune responses in lung granulomas during mtb/HIV co-infection: implications for pathogenesis and therapy
HIV and TB are the cause of significant worldwide mortality and pose a grave danger to the
global public health. TB is the leading cause of death in HIV-infected persons, with one in …
global public health. TB is the leading cause of death in HIV-infected persons, with one in …
Advances in the study of myeloid-derived suppressor cells in infectious lung diseases
MN Zhang, YL Yuan, SH Ao - Frontiers in Immunology, 2023 - frontiersin.org
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
cells capable of inhibiting T-cell responses. MDSCs have a crucial role in the regulation of …
cells capable of inhibiting T-cell responses. MDSCs have a crucial role in the regulation of …
Sildenafil, a type-5 phosphodiesterase inhibitor, fails to reverse myeloid-derived suppressor cell-mediated T cell suppression in cells isolated from tuberculosis …
VN Leukes, ST Malherbe, A Hiemstra… - Frontiers in …, 2022 - frontiersin.org
Successful TB treatment is hampered by increasing resistance to the two most effective first-
line anti-TB drugs, namely isoniazid and rifampicin, thus innovative therapies focused on …
line anti-TB drugs, namely isoniazid and rifampicin, thus innovative therapies focused on …
Role and Interrelationship Between Myeloid-Derived Suppressor Cells and CD4+ T Cells in Different Types of Infections: A Review
S Basak, A Ghosh, A Biswas, D Bhattacharya… - Proceedings of the …, 2024 - Springer
Abstract Myeloid-Derived Suppressor Cells (MDSCs), also known as 'Natural Suppressor
Cells (NSCs)','Immature Myeloid Cells,(IMCs), or 'Myeloid Suppressor Cells'(MSCs), are …
Cells (NSCs)','Immature Myeloid Cells,(IMCs), or 'Myeloid Suppressor Cells'(MSCs), are …