Regionalized immune surveillance relies on the concerted efforts of diverse memory T cell
populations. Of these, tissue-resident memory T (TRM) cells are strategically positioned in …

CD8 T cells expressing granzyme K are enriched in synovial tissue from patients with
rheumatoid arthritis and in tissues affected by several other autoimmune diseases. The roles …

Immune-mediated inflammatory diseases (IMIDs) are typically characterised by relapsing
and remitting flares of inflammation. However, the unpredictability of disease flares impedes …

HLA-B* 27 was one of the first HLA alleles associated with an autoimmune disease, ie, axial
spondyloarthritis (axSpA) and acute anterior uveitis (B27AAU), which cause joint and eye …

Genetic variation in the human leukocyte antigen (HLA) loci is associated with risk of
immune-mediated diseases, but the molecular effects of HLA polymorphism are unclear …

Psoriatic arthritis (PsA) is part of the psoriatic disease spectrum and is characterized by a
chronic inflammatory process that affects entheses, tendons and joints. Cytokines produced …

Immune-related skin diseases represent a collective of dermatological disorders intricately
linked to dysfunctional immune system processes. These conditions are primarily …

In rheumatoid arthritis, juvenile idiopathic arthritis and other forms of inflammatory arthritis,
the immune system targets certain joints but not others. The pattern of joints affected varies …

Cellular phenotype and function are altered in different microenvironments. For targeted
therapies it is important to understand site-specific cellular adaptations. Juvenile idiopathic …

Regulatory T cells (Tregs) are immune regulatory T cells that are vital for controlling
inflammation. The role of Tregs in inflammatory diseases namely Psoriatic Arthritis (PsA) is …