The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

Improvements in health care and lifestyle have led to an elevated lifespan and increased
focus on age-associated diseases, such as neurodegeneration, cardiovascular disease …

The receptor for advanced glycation endproducts (RAGE) is an ubiquitous, transmembrane,
immunoglobulin-like receptor that exists in multiple isoforms and binds to a diverse range of …

ABSTRACT RAGE is a key molecule in the onset and sustainment of the inflammatory
response. New studies indicate that RAGE might represent a new link between the innate …

The immune system has evolved to respond not only to pathogens, but also to signals
released from dying cells. Cell death through necrosis induces inflammation, whereas …

Recently, it has been proposed that the receptor for advanced glycation end-products
(RAGE) plays a crucial role in damaging cellular processes, such as neuroinflammation …

Abstract HMGB1 (High-Mobility Group Box-1) is a nuclear protein that acts as an
architectural chromatin-binding factor involved in the maintenance of nucleosome structure …

Ageing is a composite process that involves numerous changes at the cellular, tissue, organ
and whole-body levels. These changes result in decreased functioning of the organism and …

The receptor for advanced glycation endproducts (RAGE) mediates responses to cell
danger and stress. When bound by its many ligands (which include advanced glycation …

The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of
the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE …