The exponential growth of big data in RNA biology (RB) has led to the development of deep
learning (DL) models that have driven crucial discoveries. As constantly evidenced by DL …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Gene regulatory elements are central drivers of phenotypic variation and thus of critical
importance towards understanding the genetics of complex traits. The Functional Annotation …

Diagnostics require precision and predictive ability to be clinically useful. Integration of multi-
omic with clinical data is crucial to our understanding of disease pathogenesis and …

The functions of non-coding regulatory elements (NCREs), which constitute a major fraction
of the human genome, have not been systematically studied. Here we report a method …

Mouse models have been engineered to reveal the biological mechanisms of human
diseases based on an assumption. The assumption is that orthologous genes underlie …

The last two decades have seen impressive advances in functional genomics, but we are
still a long way from understanding the complexity of gene function. Here, we pose …

The accumulation of large epigenomics data consortiums provides us with the opportunity to
extrapolate existing knowledge to new cell types and conditions. We propose Epitome, a …

A fundamental challenge in molecular biology is to understand how evolving genomes can
acquire new functions. Several recent studies have underscored how non-conserved …

In a human cell, DNA is packed in histones, RNA, and chromatin-associated proteins,
forming a cohesive gel. At any given moment, only a specific subset of the proteome has …