TLR agonists as vaccine adjuvants targeting cancer and infectious diseases

M Luchner, S Reinke, A Milicic - Pharmaceutics, 2021 - mdpi.com
Modern vaccines have largely shifted from using whole, killed or attenuated pathogens to
being based on subunit components. Since this diminishes immunogenicity, vaccine …

Toll‐Like Receptor‐Based Strategies for Cancer Immunotherapy

S Pahlavanneshan, A Sayadmanesh… - Journal of …, 2021 - Wiley Online Library
Toll‐like receptors (TLRs) are expressed and play multiple functional roles in a variety of
immune cell types involved in tumor immunity. There are plenty of data on the …

Dendritic cells and cancer: from biology to therapeutic intervention

B Wylie, C Macri, JD Mintern, J Waithman - Cancers, 2019 - mdpi.com
Inducing effective anti-tumor immunity has become a major therapeutic strategy against
cancer. Dendritic cells (DC) are a heterogenous population of antigen presenting cells that …

Toll‐like receptors (TLRs) in cancer; with an extensive focus on TLR agonists and antagonists

A Keshavarz, A Pourbagheri‐Sigaroodi, P Zafari… - IUBMB …, 2021 - Wiley Online Library
At the forefront of the battle against pathogens or any endogenously released molecules, toll‐
like receptors (TLRs) play an important role as the most noble pattern recognition receptors …

Regulatory roles of transcription factors T-bet and Eomes in group 1 ILCs

Y Liao, Y Zheng, R Zhang, X Chen, J Huang… - International …, 2024 - Elsevier
T-bet and Eomes, both T-box transcription factors, have been extensively studied for their
critical roles in the differentiation and functional maintenance of various immune cells. In this …

Engineering therapeutic strategies in cancer immunotherapy via exogenous delivery of toll-like receptor agonists

S Jeong, Y Choi, K Kim - Pharmaceutics, 2021 - mdpi.com
As a currently spotlighted method for cancer treatment, cancer immunotherapy has made a
lot of progress in recent years. Among tremendous cancer immunotherapy boosters …

The dysbiosis signature of Fusobacterium nucleatum in colorectal cancer-cause or consequences? A systematic review

M Ranjbar, R Salehi, S Haghjooy Javanmard… - Cancer Cell …, 2021 - Springer
Colorectal cancer (CRC) is the third most common cause of cancer globally and the fourth
attributable cause of mortality and morbidity due to cancer. An emerging factor contributing …

Direct detection of bacteremia by exploiting host-pathogen interactions of lipoteichoic acid and lipopolysaccharide

JZ Kubicek-Sutherland, DM Vu, A Noormohamed… - Scientific reports, 2019 - nature.com
Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality
rates are the highest in the world. The early diagnosis of bacteremia and initiation of …

Natural killer cells and thyroid diseases

EK Lee, JB Sunwoo - Endocrinology and Metabolism, 2019 - synapse.koreamed.org
Abnormal production of thyroid hormone is one of the common endocrine disorders, and
thyroid hormone production declines with age. The aging process also negatively affects the …

Multimodal Strategy in Localized Merkel Cell Carcinoma: Where Are We and Where Are We Heading?

G Ricco, E Andrini, G Siepe, C Mosconi… - International journal of …, 2021 - mdpi.com
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumor of the skin whose
incidence is rising. Multimodal treatment is crucial in the non-metastatic, potentially curable …