The construction of high-performance microbial cell factories (MCFs) is the centerpiece of
biomanufacturing. However, the complex metabolic regulatory network of microorganisms …

Methanotrophy is the ability of an organism to capture and utilize the greenhouse gas,
methane, as a source of energy-rich carbon. Over the years, significant progress has been …

Genome-scale metabolic models (GEMs) have been widely employed to predict
microorganism behaviors. However, GEMs only consider stoichiometric constraints, leading …

Pseudomonas stutzeri A1501 is a non-fluorescent denitrifying bacteria that belongs to the
gram-negative bacterial group. As a prominent strain in the fields of agriculture and …

Formate as an ideal mediator between the physicochemical and biological realms can be
obtained from electrochemical reduction of CO 2 and used to produce bio-chemicals. Yet …

Levan is a fructan polymer with many industrial applications such as the formulation of
hydrogels, drug delivery, and wound healing, among others. To this end, metabolic systems …

Constructing efficient cell factories requires the rational design of metabolic pathways, yet
quantitatively predicting the potential pathway for breaking stoichiometric yield limit in hosts …

Microbial communities are shaped by the complex interactions among organisms and the
environment. Genome-scale metabolic models (GEMs) can provide deeper insights into the …

Background and objective Clinical pharmacological modeling and statistical analysis
software is an essential basic tool for drug development and personalized drug therapy. The …

Synthetic biology is contributing to the advancement of the global net‐negative carbon
economy, with emphasis on formate as a member of the one‐carbon substrate garnering …