The overall success of human reproduction, either spontaneously or after IVF, is highly
dependent upon maternal age. The main reasons for age-related infertility include reduced …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA
(mtDNA) copy number and function decline with age in various tissues. There is increasing …

The ovarian system comprises vital organs in females and is of great significance for the
maintenance of reproductive potential and endocrine stability. Although complex …

Oxidative stress has been proposed as a key contributor to lifestyle-and age-related
diseases. Because free radicals play an important role in various processes such as …

Oocytes and preimplantation embryos require careful regulation of the redox environment
for optimal development both in vivo and in vitro. Reactive oxygen species (ROS) are …

Endometriosis an important cause of female infertility and seriously impact physical and
psychological health of patients. Endometriosis is now considered to be a public health …

Ageing is a process characterized by a progressive decline in cellular function, organismal
fitness and increased risk of age-related diseases and death. Several hundred theories …

It is well established that age-related decline of the biological capacity of a woman to
reproduce is primarily related to the poor developmental potential of her gametes. This …

Physiological levels of reactive oxygen species (ROS) play an important regulatory role
through various signaling transduction pathways in folliculogenesis, oocyte maturation …